R-1479 (4'-Azidocytidine) 是一种核苷类似物，是特异性的 HCV RNA 依赖性 RNA 聚合酶 (RdRp) 抑制剂。R-1479 在 HCV 亚基因组复制体系中抑制 HCV 复制，IC₅₀ 为 1.28 μM。

R-1479 (4-Azidocytidine), a nucleoside analogue, is a specific inhibitor of RNA-dependent RNA polymerase (RdRp) of HCV. R-1479 inhibits HCV replication in the HCV subgenomic replicon system (IC 50 =1.28 μM).

Solid

IC50: 1.28 μM (HCV replication)

R-1479 (R1479) inhibits HCV RNA replication with a mean IC50 value of 1.28 μM when measured as dose-dependent reduction of Renillaluciferase activity after a 72 h incubation of proliferating replicon cells. R-1479 shows no effect on cell viability or proliferation of HCV replicon or Huh-7 cells at concentrations up to 2 mM. The most potent and non-cytotoxic derivative is R-1479 with an IC50 of 1.28 μM in the HCV replicon system. The triphosphate of R-1479 is prepared and shown to be an inhibitor of RNA synthesis mediated by NS5B (IC50=320 nM), the RNA polymerase encoded by HCV. R-1479 displays good activity in the replicon assay with no measurable cytotoxic or cytostatic effect. has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature in continental US; may vary elsewhere.

Powder -20°C 3 years；4°C 2 years

[1]. Klumpp K, et al. The novel nucleoside analog R1479 (4-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture. J Biol Chem. 2006 Feb 17;281(7):3793-9.
[2]. Smith DB, et al. Design, synthesis, and antiviral properties of 4-substituted ribonucleosides as inhibitors of hepatitis C virus replication: the discovery of R1479. Bioorg Med Chem Lett. 2007 May 1;17(9):2570-6.

In Vitro: DMSO : 100 mg/mL (351.83 mM; Need ultrasonic)配制储备液