NOD-IN-1|132819-92-2|-陌孚医药/Medlife

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NOD-IN-1

目录号: PL01116 纯度: ≥99%

NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂，IC50 值分别为 5.74 μM 和 6.45 μM。

CAS No. :132819-92-2

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中文名称	NOD-IN-1
中文别名	1-[(4-甲基苯基)磺酰基]-1H-吲哚-2-羧酸乙酯;NOD-IN-1
英文名称	NOD-IN-1
英文别名	NOD-IN-1;1H-Indole-2-carboxylic acid, 1-[(4-methylphenyl)sulfonyl]-, ethyl ester;MDK19922;ethyl 1-tosyl-1H-indole-2-carboxylate;1-(4-Methylphenyl)sulfonyl-1H-indole-2-carboxylic acid ethyl ester;1-(Toluene-4-sulfonyl)-1H-indole-2-carboxylic acid ethyl ester;BCP24808;BDBM50533841;J3.568.813G;ethyl 1-(4-methylphenyl)sulfonylindole-2-carboxylate;1-(p-Tolylsulfonyl)-1H-indole-2-carboxylic acid ethyl ester;1-(4-Methylphenyl)sulfonyl-1H-indol-2-carboxylic aci
Cas No.	132819-92-2
分子式	C₁₈H₁₇NO₄S
分子量	343.40
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	NOD-IN-1 是一种有效的核苷酸结合寡聚化结构域 (NOD) 样受体 NOD1 和 NOD2 的抑制剂，IC₅₀ 值分别为 5.74 μM 和 6.45 μM。
生物活性	NOD-IN-1 is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 and NOD2, with IC 50 of 5.74 μM and 6.45 μM, respectively.
性状	Solid
IC50 & Target[1][2]	IC50: 5.74 μM (NOD1), 6.45 μM (NOD2)
体外研究(In Vitro)	NOD-IN-1 (compound 4) is potent mixed inhibitor of NOD1 and NOD2, displaying a balanced inhibitory activity on both targets in the low micromolar range. NOD-IN-1 (IC50 (NOD1)=5.74 μM; IC50 (NOD2)=6.45 μM) is identified as the best of the series, possessing NOD1- and NOD2-inhibitory activities in the lower micromolar range. These results show that NOD-IN-1 is 7-fold less potent than Noditinib-1 in terms of NOD1 inhibition and completely devoid of selective activity for NOD1 or NOD2 as opposed to Noditinib-1. NOD-IN-1 exhibits balanced dual activities of less than 10 μM on the two targets. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Kecek Plesec K, et al. Identification of indole scaffold-based dual inhibitors of NOD1 and NOD2. Bioorg Med Chem. 2016 Nov 1;24(21):5221-5234.

溶解度数据	In Vitro: DMSO : 100 mg/mL (291.21 mM; Need ultrasonic)配制储备液

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