TPI-1|79756-69-7|-陌孚医药/Medlife

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TPI-1

目录号: PL01075 纯度: ≥98%

CAS No. :79756-69-7

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中文名称	TPI-1
中文别名	TPI-1
英文名称	TPI-1
英文别名	TPI-1;TPI 1;2-(2,5-dichlorophenyl)cyclohexa-2,5-diene-1,4-dione;2-(2,5-Dichlorophenyl)-1,4-benzoquinone;2,5-Cyclohexadiene-1,4-dione, 2-(2,5-dichlorophenyl)-;2',5'-Dichloro-[1,1'-biphenyl]-2,5-dione;2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione;2-(2',5'-dichlorophenyl)-1,4-benzoquinone;CBMicro_042121;Tyrosine Phosphatase Inhibitor 1;BCP28977;NSC731240;STK338097;AK688821
Cas No.	79756-69-7
分子式	C₁₂H₆Cl₂O₂
分子量	253.08
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	TPI-1是SHP-1的抑制剂；抑制重组SHP-1的IC₅₀值为40 nM。
生物活性	TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC 50 of 40 nM.
性状	Solid
IC50 & Target[1][2]	IC50: 40 nM (recombinant SHP-1)
体外研究(In Vitro)	SHP-1 has been implicated as a potential cancer therapeutic target. TPI-1 is effective starting at 10 ng/mL in increasing SHP-1 phospho-substrates pLck-pY394. TPI-1 selectively increases SHP-1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but has little effects on pERK1/2 or pLck-pY505. TPI-1 induces mouse splenic-IFNγ cells and induces IFNγ cells in human peripheral blood. has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	TPI-1 inhibits the growth of B16 melanoma tumors in mice at a tolerated oral dose in a T cell-dependent manner but has little effects on B16 cell growth in culture. TPI-1 thus also increases pLck-pY394 and IFNγ cells in mice. TPI-1 also inhibits B16 tumor growth and prolongs tumor mice survival as a tolerated s.c. agent. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. Kundu S, et al. Novel SHP-1 inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun 1;184(11):6529-36.

溶解度数据	In Vitro: DMSO : 50 mg/mL (197.57 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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