Paquinimod|248282-01-1|(帕奎莫德; ABR-215757; ABR 25757)-陌孚医药/Medlife

您当前的位置：

Paquinimod (Synonyms: 帕奎莫德; ABR-215757; ABR 25757)

目录号: PL01067 纯度: ≥99%

CAS No. :248282-01-1

商品编号	规格	价格	会员价
PL01067-10mg	10mg	¥7350.00	请登录
PL01067-50mg	50mg	¥7232.00	请登录
PL01067-100mg	100mg	¥12054.00	请登录
PL01067-200mg	200mg	询价	询价
PL01067-500mg	500mg	询价	询价
PL01067-10mM*1mLinDMSO	10mM*1mLinDMSO	¥2652.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Paquinimod
中文别名	N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenylquinoline-3-carboxamide;帕奎莫德
英文名称	Paquinimod
英文别名	N,5-diethyl-4-hydroxy-1-methyl-2-oxo-n-phenylquinoline-3-carboxamide;UNII-HB76GLG27V;N-ethyl-N-phenyl-1,2-dihydro-5-ethyl-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide;Paquinimod [INN];N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide;N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide;N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide;CHEMBL67776;SureCN1573633;Paquinimod;ABR-215757;N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-3-quinolinecarboxamide;UNII-HB76GLG27V; N-ethyl-N-phenyl-1,2-dihydro-5-ethyl-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide; Paquinimod [INN]; N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide; N-ethyl-N-phenyl-5-ethyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxo-quinoline-3-carboxamide; N-ethyl-N-phenyl-1,2-dihydro-4-hydroxy-5-ethyl-1-methyl-2-oxo-quinoline-3-carboxamide; CHEMBL67776; SureCN1573633; Paquinimod; ABR-215757; N-ethy;ABR 25757;N,5-diethyl-4-hydroxy-1-methyl-2-oxo-N-phenyl-1,2-dihydroquinoline-3-carboxamide;HB76GLG27V;Paquinimod; ABR 25757;ABR25757;BCP29381;ABR?215757;DB13118;SB17375;BP164809
Cas No.	248282-01-1
分子式	C₂₁H₂₂N₂O₃
分子量	350.41
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情

Paquinimod (ABR 25757) 是一种 S100A8/S100A9 的特异性抑制剂，通过降低 SARS-CoV-2 感染小鼠的病毒载量来用于肺炎的研究。

生物活性

Paquinimod (ABR 25757) is a specific inhibitor of S100A8/S100A9. Paquinimod rescues the pneumonia with substantial reduction of viral loads in SARS-CoV-2-infected mice.

性状

Solid

IC50 & Target[1][2]

S100A9

体内研究(In Vivo)

S100A9 is a calcium-binding protein of the S100 family. Paquinimod is an immunomodulatory compound preventing S100A9 binding to TLR-4. Prophylactic treatment with S100A9 inhibitor Paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Paquinimod is a potent inhibitor of insulitis and diabetes development in the NOD mouse. To assess the preventive efficacy of Paquinimod on diabetes development in female NOD mice, groups of mice are treated with daily doses of 0.04, 0.2, 1, and 5 mg/kg/day of Paquinimod from week 10 of age until week 20 of age. Glycosuria is analyzed on a weekly basis from 10 weeks of age until the endpoint of the experiment at 40 weeks of age. There is a clear dose-dependent reduction in diabetes development in the Paquinimod-treated mice. has not independently confirmed the acc

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder -20°C 3 years；4°C 2 years

ClinicalTrial

参考文献

[1]. Schelbergen RF, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74(12):2254-8.
[2]. Tahvili S, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One. 2018 May 9;13(5):e0196598.

溶解度数据	In Vitro: DMSO : 62.5 mg/mL (178.36 mM; Need ultrasonic)H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)配制储备液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品

The molarity calculator equation

The dilution calculator equation