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伊曲康唑.

(Synonyms: 伊曲康唑 ; R51211)

目录号: PC79074 纯度: ≥98%

CAS No. :84625-61-6

商品编号	规格	价格	会员价
PC79074-20mg	20mg	¥84.75	请登录
PC79074-100mg	100mg	¥425.00	请登录
PC79074-200mg	200mg	¥1082.00	请登录
PC79074-1g	1g	¥3185.00	请登录
PC79074-10mM (in 1mL DMSO)	10mM (in 1mL DMSO)	¥764.00	请登录

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中文名称	伊曲康唑.
中文别名	4-羧基-2-[(1R)-1-[[2-[(2,5-二氯苯甲酰基)氨基]乙酰基]氨基]-3-甲基丁基]-6-氧代-1,3,2-二氧硼杂环己-4-乙酸;MLN9708 抑制剂;洛沙坦杂质B;依扎佐咪MLN9708;枸橼酸艾莎佐米MLN9708;枸橼酸埃沙佐米;Ixazomib 柠檬酸盐;埃沙佐米柠檬酸盐;柠檬酸艾沙佐米;艾沙唑咪
英文名称	Itraconazole
英文别名	MLN9708;4-(carboxymethyl)-2-((R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutyl)-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;4-(carboxymethyl)-2-[(1R)-1-[[2-[(2,5-dichlorobenzoyl)amino]acetyl]amino]-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;Ixazomib (MLN2238);MLN9708 ( MLN-9708,Ixazomib);MLN 9708;Ixazomib Citrate (MLN9708);4-(carboxymethyl)-2-[(1R)-1-{2-[(2,5-dichlorophenyl)formamido]acetamido}-3-methylbutyl]-6-oxo-1,3,2-dioxaborinane-4-carboxylic acid;Nattokinase;4-Carboxy-2-[(1R)-1-[[2-[(2,5-dich
Cas No.	84625-61-6
分子式	C₃₅H₃₈Cl₂N₈O₄
分子量	705.65
包装储存	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

产品详情	抗真菌剂，Itraconazole是抗真菌剂。
生物活性	Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
性状	Solid
IC50 & Target[1][2]	Fungal IC50: ~800 nM (Hedgehog signaling pathway) 14α-demethylase (cytochrome P450 enzyme)
体外研究(In Vitro)	Itraconazole has anti-proliferation of HUVEC (IC50 of 0.16 μM). Itraconazole inhibits endothelial cell cycle progression at the G1 phase 体外研究. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Itraconazole (75-100 mg/kg; oral gavage; twice per day; for 18 days; female outbred athymic nude mice) treatment suppresses Hh pathway activity and the growth of medulloblastoma in a mouse allograft model. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transportation.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
描述&特点	抗真菌剂，Itraconazole是抗真菌剂。
参考文献	[1]. Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17(4): p. 388-99. [Information] [2]. Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2(4): p. 263-70. [Information] [3]. Pace JR, et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28;59(8):3635-49. [Information] [4]. Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017;140:37-44.

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[1]. Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17(4): p. 388-99. [Information]

[2]. Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2(4): p. 263-70. [Information]

[3]. Pace JR, et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28;59(8):3635-49. [Information]

[4]. Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017;140:37-44.

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

伊曲康唑.

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