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L-Canavanine sulfate

iNOS抑制剂，L-Canavanine sulfate 是诱导型 NO 合酶 (NO synthase) 的选择性抑制剂。

目录号: PC15152 纯度: ≥98%

CAS No. :2219-31-0

商品编号	规格	价格	会员价
PC15152-50mg	50mg	¥588.00	请登录
PC15152-100mg	100mg	¥823.20	请登录
PC15152-10mM (in 1mL H2O)	10mM (in 1mL H2O)	¥646.80	请登录

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中文名称	L-Canavanine sulfate
中文别名	L-刀豆氨酸硫酸盐;硫酸-L-刀豆氨基酸;L-刀豆氨酸硫酸盐水合物;L-Canavanine Sulfate Hydrate L-刀豆氨酸硫酸盐水合物;L-刀豆氨酸硫酸;N-甲磺酰咪唑;刀豆氨酸;L-硫酸刀豆氨酸;4-胍氧丁胺酸硫酸盐;硫酸-L-刀豆氨基酸水合物;L-硫酸刀豆氨酸水合物
英文名称	L-Canavanine sulfate
英文别名	Canavanine sulfate;L-Canavanine Sulphate;L-Canavanine Sulfate Hydrate;CANAVANINE SULFATE, L-(P);L -CANAVANINE SULFATE;CANAVANINE SULFATE,L;canavanine sulphate;L-CANAVANINE SULFATE SALT;O-Guanidino-L-homoserin,Sulfat;O-guanidino-L-homoserine,sulfate;O-[(Aminoiminomethyl)amino]-L-homoserine sulfate (1:1);L-Canavanine sulfate
Cas No.	2219-31-0
分子式	C₅N₄O₃H₁₃
分子量	177.18
包装储存	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

生物活性	L-Canavanine sulfate is a selective inhibitor of inducible NO synthase.
性状	Solid
IC50 & Target[1][2]	NO synthase
体外研究(In Vitro)	L-Canavanine sulfate (L-CAV) causes only a limited degree of cytotoxicity in HeLa, Hep G2, and SK-HEP-1 cells when given alone in arginine-rich media with IC₅₀ values ranging from 5 to 10 mM. In HaCaT keratinocyte cell line, IC₅₀ of L-Canavanine sulfate exceeds the concentration of 10 mM, indicating low cytotoxicity in normal cells 体外研究. In arginine-free media, IC₅₀ of L-Canavanine sulfate in HeLa, Hep G2, and SK-HEP-1 cells are 0.21±0.04; 0.64±0.16; and 1.18±0.14 mM, respectively. L-Canavanine sulfate, which is hardly toxic alone, potentiates the cytotoxicity of vinblastine (VIN) and paclitaxel (PTX) in HeLa and hepatocellular carcinoma cells. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Administration of L-Canavanine sulfate (100 mg/kg) produces a moderate increase in mean arterial pressure of 20 mm Hg, returns blood pressure to near basal levels and completely attenuates the lipopolysaccharide-induced hypotension. All, but one, endotoxaemic rats dosed with L-Canavanine sulfate (100 mg/kg) survive for 6 h post lipopolysaccharide, after which time the experiment is terminated (n=7). L-canavanine inhibits DNA synthesis by Li 210 cells in vivo and significantly increases the lifespan of animals bearing the Li 210 leukemia. An optimal dose of 18 g/kg produces a peak increase in lifespan of 44%. The therapeutic dose range is narrow, and a dose of 24 g/kg causes death due to drug toxicity. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transportation.
储存方式	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
结构分类	Ketones, Aldehydes, Acids
来源	Plants other families
参考文献	[1]. Teale DM, et al. L-canavanine restores blood pressure in a rat model of endotoxic shock. Eur J Pharmacol. 1994 Dec 12;271(1):87-92. [Information] [2]. Nurcahyanti AD, et al. Cytotoxic potentiation of vinblastine and paclitaxel by L-canavanine in human cervical cancer and hepatocellular carcinoma cells. Phytomedicine. 2015 Dec 15;22(14):1232-7. [Information] [3]. Green MH, et al. Antitumor activity of L-canavanine against L1210 murine leukemia. Cancer Res. 1980 Mar;40(3):535-7. [Information]

溶解度数据

体外研究:

H₂O : 100 mg/mL (364.63 mM; Need ultrasonic and warming)

配制储备溶液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6463 mL	18.2315 mL	36.4631 mL
5 mM	0.7293 mL	3.6463 mL	7.2926 mL
10 mM	0.3646 mL	1.8232 mL	3.6463 mL

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。

体内研究:

建议根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都建议先按照 体外研究 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

建议依照次序添加每种溶剂： PBS
Solubility: 50 mg/mL (182.32 mM); Clear solution; Need ultrasonic

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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