Lupeol|545-47-1|(羽扇豆醇; Clerodol; Monogynol B; Fagarasterol)-陌孚医药/Medlife

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Lupeol (Synonyms: 羽扇豆醇; Clerodol; Monogynol B; Fagarasterol)

目录号: PC64081 纯度: ≥98.0%

CAS No. :545-47-1

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中文名称	Lupeol
中文别名	羽扇豆醇;Lupeol 羽扇豆醇标准品;羽扇豆醇(RG)(PLEASE CALL);羽扇豆醇（标准品）;羽扇豆醇,Lupeol,植物提取物,标准品,对照品;羽扇豆醇Lupeol;20(29)-羽扇烯-3β-醇;3β-羟基-20(29)-羽扇烯;蛇麻醇酯;羽扇醇;羽扇豆醇(羽扇醇,羽扇豆醇酯,蛇麻醇酯);羽扇豆醇酯;羽扇豆醇；545-47-1 ；lupeol
英文名称	Lupeol
英文别名	lupeol;Fagarasterol;Lup-20(29)-en-3b-ol;LUPEOL(AS);LUPEOL(AS) PrintBack;LUPEOL(P);LUPEOL(RG)(PLEASE CALL) PrintBack;Lupeol, froM Crataegus pinnatifida;20(29)-Lupen-3β-ol;B-VISCOL;Cautchicol;Clerodol;Fagarsterol;Lupenol;MONOGYNOL;monogynolb;β-Viscol;(3beta)-Lup-20(29)-en-3-ol;Lup-20(29)-en-3-ol;[ "Lup-20(29)-en-3-ol" ];Monogynol B
Cas No.	545-47-1
分子式	C₃₀H₅₀O
分子量	426.72
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Lupeol (Clerodol; Monogynol B; Fagarasterol) is an active pentacyclic triterpenoid, has anti-oxidant, anti-mutagenic, anti-tumor and anti-inflammatory activity. Lupeol is a potent androgen receptor (AR) inhibitor and can be used for cancer research, especially prostate cancer of androgen-dependent phenotype (ADPC) and castration resistant phenotype (CRPC).

性状

Solid

IC50 & Target[1][2]

Androgen receptor

体外研究(In Vitro)

Lupeol, an effective AR inhibitor, can be developed as a potential agent to treat humanprostate cancer (CaP). Lupeol (10–50 μM) treatment for 48 h results in a dose-dependent growth inhibition ofandrogen-dependent phenotype (ADPC) cells viz., LAPC4 and LNCaP cells with an IC50 of 15.9 and 17.3 μM, respectively. Lupeol also inhibits the growth of 22Rν_1 with an IC50 of 19.1 μM. Further, Lupeol inhibits the growth of C4-2b cells with an IC50 of 25 μM. Lupeol has the potential to inhibit the growth of CaP cells of both ADPC and CRPC phenotype. Androgens by activating AR are known to drive the growth of CaP cells.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Lupeol is an effective agent that has the potential to inhibit the tumorigenicity of CaP cells in vivo. At the conclusion of the study on day 56, the total circulating serum-PSA levels (secreted by the implanted tumor cells) are measured. At 56thday post-implantation, PSA levels are observed between 11.95-12.79 ng/mL in control animals with LNCaP-tumors and C4-2b-tumors, respectively. However, Lupeol-treated counterpart animals exhibits reduced serum-PSA levels in a range of 4.25-7.09 ng/mL. Tumor tissues of animals receiving Lupeol treatment exhibits reduced serum-PSA levels as compared to control.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Terpenoids
Triter

来源

Plants
other fami

溶解度数据	体外研究: Ethanol : 14.29 mg/mL(33.49 mM;ultrasonic and warming and heat to 60°C) DMSO : 2 mg/mL(4.69 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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