Isovitexin|38953-85-4|(异牡荆黄素; Saponaretin; Homovitexin)-陌孚医药/Medlife

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Isovitexin (Synonyms: 异牡荆黄素; Saponaretin; Homovitexin)

目录号: PC60346 纯度: ≥99%

CAS No. :38953-85-4

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中文名称	Isovitexin
中文别名	异牡荆黄素;4H-1-Benzopyran-4-one,6-尾-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-;异黄链霉素;异牡荆苷;异牡荆素;异牧荆素(AS);异牧荆素(P);标准品异牡荆素;对照品
英文名称	Isovitexin
英文别名	Flavone,6-b-D-glucopyranosyl-4',5,7-trihydroxy-(7CI);Homovitexin (6CI);6-C-Glucosylapigenin;6-C-b-D-Glucopyranosylapigenin;Apigenin 6-C-b-D-glucoside;Isovitexin;Isovitexin (C-6 isomer);Saponaretin;ISOVITEXIN(AS) PrintBack;ISOVITEXIN(P) PrintBack;Isovitexin, froM Crataegus pinnatifida;6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;[ "" ];4H-1-Benzopyran-4-one,6-尾-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-;isovitexin-7-olate;6C-hexosyl apigenin;6-C-glucosyl-apigenin;6-C-glucosyl-4',5,7-trihydroxyflavone;6-(beta-D-glucopyranosyl)-2-hydroxynaringenin;(1S)-1,5-anhydro-1-[5-hydroxy-2-(4-hydroxyphenyl)-7-oxido-4-oxo-4H-chromen-6-yl]-D-glucitol;Homovitexin;Apigenin-6-C-glucoside;6-Glucosylapigenin;ISOVITEXIN WITH;Apigenin 6-C-glucoside;KTQ9R9MS0Q;4H-1-Benzopyran-4-one, 6-beta-D-glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-;Isoavroside;(1S)-1,5-anhydro-1-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-6-yl]-D-glucitol;SMR001215816;beta-D-isovitexin;Apigenin 6-C-beta-glucopyranoside;C01714;MLS000563041;MLS002473147
Cas No.	38953-85-4
分子式	C₂₁H₂₀O₁₀
分子量	432.38
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Isovitexin is a flavonoid isolated from passion flower, Cannabis and, and the palm, possesses anti-inflammatory and anti-oxidant activities; Isovitexin acts like a JNK1/2 inhibitor and inhibits the activation of NF-κB.
性状	Solid
IC50 & Target[1][2]	JNK1 JNK2
体外研究(In Vitro)	Isovitexin protects against LPS-induced oxidative damage by suppressing intracellular ROS generation, and also attenuates the effect of H2O2 on cell viability. Isovitexin (0-100 μg/mL) with LPS (2 μg/mL) is not cytotoxic to RAW 264.7 cells, but 200 μg/mL Isovitexin shows significant cytotoxicity. Isovitexin (25, 50 μg/mL) inhibits LPS-induced increases in TNF-α, IL-6, iNOS, and COX-2 levels. Isovitexin (25, 50 μg/mL) also suppresses the IκBα phosphorylation and degradation in RAW 264.7 cells, and such an effect is consistent with that of JNK1/2 inhibitor.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Isovitexin (50 and 100 mg/kg, i.p.) causes less severe histopathological changes in the lung sections, and reduces inflammatory cell count in LPS-induced mice. Isovitexin (50 and 100 mg/kg, i.p.) protects against LPS-induced inflammation and oxidative stress in LPS-induced ALI mice by decreasing TNF-α and IL-6 production, ROS generation, and MPO and MDA content, increasing SOD and GSH levels and effectively inhibiting the protein expression of iNOS and COX-2. Isovitexin (25, 50, 100 mg/kg) dose-dependently reduces the survival rate of LPS/D-gal induced hepatic injury in mice. Isovitexin also inhibits NF-κB activation and up-regulates Nrf2 and HO-1 induced by LPS/D-gal in mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Flavonoids Flavon
来源	Plants

溶解度数据	体外研究: DMSO : 25 mg/mL(57.82 mM;Need ultrasonic) 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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