10-Deacetyl-7-xylosyl paclitaxel|90332-63-1|(10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside)-陌孚医药/Medlife

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10-Deacetyl-7-xylosyl paclitaxel (Synonyms: 10-Deacetyl-7-xylosyltaxol; 10-Deacetylpaclitaxel 7-Xyloside; 10-Deacetyltaxol 7-Xyloside)

目录号: PC64539 纯度: ≥99%

CAS No. :90332-63-1

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中文名称	10-Deacetyl-7-xylosyl paclitaxel
中文别名	7-木糖甙-10-脱乙酰基紫杉醇;7-木糖苷-10-脱乙酰基紫杉醇;10-去乙酰-7-木糖紫杉醇;10-脱乙酰-7-木糖基紫杉酚 (P);2,3-环氧环己酮;7--木糖--10-去乙酰基紫杉醇;7-木糖-10-去乙酰紫杉醇;7-木糖紫杉醇;7-木糖-10-去乙酰基紫杉醇
英文名称	10-Deacetyl-7-xylosyl paclitaxel
英文别名	7-Xylosyl-10-deacetyltaxol;10-Deacetyltaxol 7-xyloside;b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR,bS),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-6,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(b-D-xylopyranosyloxy)-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester;10-Deacetyl-7-xylosyl Paclitaxel;7-XYLOXYL-10-DEACETYL TAXOL;10-Deacetyl-7-xylosyltaxol;10-Deacetylpaclitaxel 7-Xyloside;b-(Benzoylamino)-a-hydroxy-benzenepropanoic acid [2aR-[2aa,4b,4ab,6b,9a(aR,bS),11a,12a,12aa,12ba]]-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodec;[ "" ];[(2S,3R,7R,9R,12S,15S)-4-Acetyloxy-15-[(2R,3S)-3-benzamido-2-hydroxy-3-phenylpropanoyl]oxy-1,12-dihy
Cas No.	90332-63-1
分子式	C₅₀H₅₇NO₁₇
分子量	943.98
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	10-Deacetyl-7-xylosyl paclitaxel is a Paclitaxel (a microtubule stabilizing agent; enhances tubulin polymerization) derivative with improved pharmacological features.IC50 value:Target: Microtubule inhibitor10-Deacetyl-7-xylosyl paclitaxel induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9. In turn, caspase-9 activated downstream caspases-3 and -6, but not caspase-8. Bid was also activated by caspase-3. Reversely, treatment with a caspase-10-specific inhibitor could not protect PC-3 cells from 7-xylosyl-10-deacetyl-paclitaxel-triggered
性状	Solid
IC50 & Target[1][2]	Traditional Cytotoxic Agents

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

结构分类

Terpenoids
Diterp

来源

Plants

溶解度数据	体外研究: DMSO : 33.33 mg/mL(35.31 mM;Need ultrasonic) H₂O : 1 mg/mL(1.06 mM;ultrasonic and warming and heat to 60°C) 配制储存液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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