Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1).

Solid

Stat-3
 EXP1
 

Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1). Artesunate treatment for 24 h causes a significant increase in the levels of reactive oxygen species (ROS) in a dose-dependent manner in both cell lines. Moreover, Western blotting shows that the levels ofγ-H2AX are significantly elevated when cancer cells are treated with Artesunate in the higher dose range for 24 h.Artesunate also shows a time-dependent effect on the level of RAD51 in A2780 and HO8910 cells. In two types of non-malignant cells, normal human fibroblasts and immortalized epithelial cells, FTE-187, the level of RAD51 is not altered by Artesunate. In A2780 cells, the level of RAD51 mRNA is indeed decreased by the addition of Artesunate, in a dose-dependent manner. Correspondingly, the promoter activity of RAD51 is significantly inhibited by Artesunate. In contrast, the RAD51 mRNA level in

Tumor growth is significantly reduced in the group receiving combined treatment of Artesunate and cisplatin (P<0.01). In comparison, Artesunate alone has no significant effect on the growth of tumor xenografts for both cell lines.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transport.

Powder； -20°C； 3 years; 4°C； 2 years；

Terpenoids
Sesqui

Plants

体外研究:
DMSO : 83.33 mg/mL(216.77 mM;Need ultrasonic)
7.5% sodium bicarbonate : 20 mg/mL(52.03 mM;Need ultrasonic)
H₂O : 0.67 mg/mL(1.74 mM;Need ultrasonic)