Corydaline|518-69-4|(紫堇碱; (+)-Corydaline; Corydalin)-陌孚医药/Medlife

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Corydaline (Synonyms: 紫堇碱; (+)-Corydaline; Corydalin)

目录号: PC63031 纯度: ≥98%

CAS No. :518-69-4

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中文名称	Corydaline
中文别名	延胡索碱甲;2,3,9.10-四甲氧基-13Α-甲基-13ΑΒ-小檗因;延胡索碱;紫堇碱;紫菫鹼;(+)-紫堇碱,延胡索甲素;延胡索碱(紫堇块茎碱);延胡索甲素;WAKO036-14971榛子蛋白质标准品;延胡索甲素（标准品）;延胡索甲素（紫堇碱）;延胡索甲素对照品;延胡索碱甲Corydaline;紫堇;紫堇碱:(延胡索甲素:Corydaline);紫堇碱标准品;紫堇灵 Corydaline;延胡索甲素(紫堇碱,延胡索碱,(+)-紫堇碱,D-紫堇碱);延胡索甲素,紫堇碱;紫堇碱,延胡索碱甲,延胡索甲素
英文名称	Corydaline
英文别名	Corydaline;(13s-e)-thyl;2,3,9,10-tetramethoxy-13-alpha-methyl-13a-beta-berbin;2,3,9,10-tetramethoxy-13-methyl-berbin;6h-dibenzo(a,g)quinolizine,5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-13-me;corydalin;(+) CORYDALINE;CORYDALINE, (+);(+)- Corydaline;(13S,13aR)-2,3,9,10-tetramethoxy-13-methyl-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline;Berbine,2,3,9,10-tetramethoxy-13-methyl;d-Corydalin;(+)-Corydaline;d-Corydaline;08N392L8VX
Cas No.	518-69-4
分子式	C₂₂H₂₇NO₄
分子量	369.45
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Corydaline ((+)-Corydaline), an isoquinoline alkaloid isolated from Corydalis yanhusuo, is an AChE inhibitor with an IC₅₀ of 226 μM. Corydaline is a μ-opioid receptor (K_i of 1.23 μM) agonist and inhibits enterovirus 71 (EV71) replication (IC₅₀ of 25.23 μM). Corydaline has anti-angiogenic, anti-allergic and gastric-emptying and antinociceptive activities.
性状	Solid
IC50 & Target[1][2]	AChE μ Opioid Receptor/MOR
体外研究(In Vitro)	Corydaline (12.5-50 μM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro. Corydaline could inhibit the viral RNA synthesis in a dose dependent manner.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. ass="cpd-vitro-list"> Western Blot Analysis-
体内研究(In Vivo)	Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Alkaloids Isoquin
来源	Plants

溶解度数据	体外研究: DMSO : 33.33 mg/mL(90.22 mM;Need ultrasonic) 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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