Anisomycin|22862-76-6|(茴香霉素; Flagecidin; Wuningmeisu C)-陌孚医药/Medlife

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Anisomycin (Synonyms: 茴香霉素; Flagecidin; Wuningmeisu C)

目录号: PC61248 纯度: ≥99%

CAS No. :22862-76-6

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中文名称	Anisomycin
中文别名	茴香霉素;Anisomycin 茴香霉素;茴香霉素(链霉菌属);茴香霉素, 来源于浅灰链霉菌;(2R,3S,4S)-2-(4-甲氧苯基)-3,4-吡咯二醇3-乙酸酯;梧宁霉素 C
英文名称	Anisomycin
英文别名	3,4-Pyrrolidinediol,2-[(4-methoxyphenyl)methyl]-, 3-acetate, (2R,3S,4S)-;Anisomycin;Anisomycin from Streptomyces griseolus;Anisomycin,(2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol3-acetate;(2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol 3-Acetate;2-p-methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine;ANISOMYCIN,STREPTOMYCES GRISEOLUS;antibioticpa-106;Wuningmeisu C;Flagecidin;(-)-Anisomycin;(2R,3S,4S)-2-(p-Methoxyphenylmethyl)-3-acetoxy-4-hydroxypyrrolidine;NSC 76712;(2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate;NSC76712;(2R,3S,4S)-2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate;Upjohn 204t3;2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate;6C74YM2NGI;MLS001066392;Anisomycin, Streptomyces griseolus;1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate;SMR00047
Cas No.	22862-76-6
分子式	C₁₄H₁₉NO₄
分子量	265.31
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system. Anisomycin is a JNK activator, which increases phospho-JNK. Anisomycin is a bacterial antibiotic.
性状	Solid
IC50 & Target[1][2]	JNK DNA synthesis
体外研究(In Vitro)	To examine whether JNK has a core role in colistin-induced neurotoxicity in PC-12 cells, an SP600125 (a highly selective inhibitor of JNK) and Anisomycin (a potent activator) are used in this study. In order to select an appropriate concentration, PC-12 cells are treated with a range of SP600125 (0-80 μM) and Anisomycin (0-20 μM) respectively for 24 h. The results show that the cells viability significantly decreases by SP600125 treatment in a concentration-dependent manner, observed at the concentrations greater than 20 μM (p<0.01). Similarly the cells viability is inhibited by Anisomycin treatment (≥8 μM) (p<0.05) .Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Anisomycin (60 mg/kg; for 4-week continuous intravenous administration) significantly decreases mouse body weight in a dose-related manner, compared with the control group. Anisomycin (15 mg/kg; for 4-week continuous intravenous administration) slightly and transiently decreases the mouse body weight. There is no significant difference of the mouse body weight in 5 mg/kg group.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Antibiotics Other
来源	Streptomyces griseolus

溶解度数据	体外研究: DMSO : ≥ 50 mg/mL(188.46 mM) H₂O : 4 mg/mL(15.08 mM;ultrasonic and warming and heat to 60°C) *≥ means soluble, but saturation unknown.

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