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Hyodeoxycholic acid

(Synonyms: 猪去氧胆酸; HDCA)

目录号: PC66871 纯度: ≥99%

Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸，为 TGR5 (GPCR19) 的激动剂，在 CHO 细胞中，EC50 值为 31.6 µM。Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸，为 TGR5 (GPCR19) 的激动剂，在 CHO 细胞中，EC50 值为 31.6 µM。

CAS No. :83-49-8

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中文名称	Hyodeoxycholic acid
中文别名	猪去氧胆酸;3α,7β-二羟基-5β-胆甾烷-24-酸;熊去氧胆酸;猪脱氧胆酸;异去氧胆酸;二羟基胆基酸;3β,6α-二羟基胆烷酸;二羟基胆烷酸;3α,7β-二羟基-5β-胆甾烷-24-;医药级猪去氧胆酸;重酒石酸去甲肾上腺素;猪去氧胆酸标准品;猪去氧胆酸（标准品）;猪去氧胆酸,BR;猪去氧胆酸[猪胆];猪去氧胆酸对照品;3α,6α-二羟基-5β-胆烷酸;3-羟基苯乙酮;细菌内毒素检查用水
英文名称	Hyodeoxycholic acid
英文别名	Hyodeoxycholic acid;UDCA;3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid;Pig Hyodeoxycholic acid;(4R)-4-((3R,5R,6S,10R,13R,17R)-3,6-Dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid;3-ALPHA,6-ALPHA-DIHYDROXY-5-ALPHA-CHOLAN-24-OIC ACID;HYODEOXYCHOLIC ACID (RG);Hyodesoxycholicacid;α-Hyodeoxycholic Acid;3'-Hydroxyacetophenone;7-deoxyhyocholicacid;HDCA;HYDROCHOLIC ACID;HYODEOXYCHOLANIC ACID;Hyodeoxycholic;Iodeoxycholic acid;Pig deoxybile acid;Hyodesoxycholic acid;.alpha.-Hyodeoxycholic acid;NSC657951;3.alpha.,6.alpha.-Dihydroxycholanic acid;3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholanic acid;3.alpha.,6.alpha.-Dihydroxy-5.beta.-cholanoic acid;NCIOpen2_007753;Oprea1_634816;Hyodeoxycholicacid
Cas No.	83-49-8
分子式	C₂₄H₄₀O₄
分子量	392.57
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
详情描述	Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸，为 TGR5 (GPCR19) 的激动剂，在 CHO 细胞中，EC50 值为 31.6 µM。Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸，为 TGR5 (GPCR19) 的激动剂，在 CHO 细胞中，EC50 值为 31.6 µM。

生物活性	Hyodeoxycholic acid is a secondary bile acid formed in the small intestine by the gut flora, and acts as a TGR5 (GPCR19) agonist, with an EC₅₀ of 31.6 μM in CHO cells.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

Hyodeoxycholic acid is a secondary hydrophilic bile acid formed in the small intestine by the gut flora, and acts as an agonist of TGR5, with an EC50 of 31.6 μM in CHO cells. Hyodeoxycholic acid (50, 100 μM) increases the expression of genes (Abca1, Abcg1, and Apoe) involved in cholesterol efflux in RAW 264.7 cells.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Hyodeoxycholic acid (HDCA; 1.25% (wt/wt)) obviously decreases fat mass and increases lean mass but does not raise the serum levels of any organ toxicity markers in LDLRKO mice. Hyodeoxycholic acid inhibits atherosclerotic lesion formation in LDLRKO at multiple sites, improves plasma lipoprotein profiles, decreases plasma glucose level and intestinal cholesterol absorption efficiency and increases daily cholesterol excretion through fecal output. Hyodeoxycholic acid also improves HDL function as measured by a cholesterol efflux assay.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

结构分类

Steroids

溶解度数据	体外研究: DMSO : ≥ 100 mg/mL(254.73 mM) H₂O : < 0.1 mg/mL (insoluble) *≥ means soluble, but saturation unknown.

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Hyodeoxycholic acid

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