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Nigericin sodium salt

(Synonyms: 尼日利亚菌素钠盐)

目录号: PC61235 纯度: ≥98.0%

Nigericin sodium salt是从吸水链霉菌中得到的一种抗生素，作为H⁺，K⁺和Pb²⁺离子载体起作用，NLRP3的激动剂。Nigericin sodium salt是从吸水链霉菌中得到的一种抗生素，作为H⁺，K⁺和Pb²⁺离子载体起作用，NLRP3的激动剂。

CAS No. :28643-80-3

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中文名称	Nigericin sodium salt
中文别名	尼日利亚菌素钠盐;尼日利亚菌素钠;9-氨基吖啶;尼日利亚菌素;日利亚菌素钠盐
英文名称	Nigericin sodium salt
英文别名	Nigericin sodium salt;Sodium (2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl]methyl]-3-methyloxan-2-yl]propanoate;Nigericin (sodium salt);Nigericin . sodium salt;Nigericin sodium salt (Antibiotic K178, Antibiotic X464, Azalomycin M, Helexin C, Polyetherin A);nigericinsodiumsaltfromstreptomyceshygroscopicus;Sodium Nigericin;Sodium(2R)-2-[(3S,6R)-6-[[(2S,4R,5R,7R,9R,10R)-2-[(5S)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-9-methoxy-2,4,10-trim;Antibiotic K178 Antibiotic X464 Azalomycin;Antibiotic K178,Antibiotic X464,Azalomycin M,Helexin C,Polyetherin A;nigericin.Na;Nigericin, sodium salt (1:1);NSC292567;Neuro_000147;Nigericin, sodium salt(1:1);BCP13661;2-[6-[[2-[5-[5-[6-Hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxol;B7644;sodium;(2S)-2-[(2R,3S,6R)-6-[[(2S,4S,5R,6R,7S,9R)-2-[(2R,5R)-5-[(2R,3S,5R)-5-[(2S,3S,5R,6R)-6-hydrox
Cas No.	28643-80-3
分子式	C₄₀H₆₇NaO₁₁
分子量	746.94
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
详情描述	Nigericin sodium salt是从吸水链霉菌中得到的一种抗生素，作为H⁺，K⁺和Pb²⁺离子载体起作用，NLRP3的激动剂。Nigericin sodium salt是从吸水链霉菌中得到的一种抗生素，作为H⁺，K⁺和Pb²⁺离子载体起作用，NLRP3的激动剂。

生物活性	Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H, K, and Pb ionophore, a NLRP3 activator.
性状	Solid
IC50 & Target[1][2]	NLRP3

体外研究(In Vitro)

Nigericin (0.1 μM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC50 of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC50 of 12.92±0.25 μmol and 15.86±0.18 μmol. Nig

体内研究(In Vivo)

Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

结构分类

Antibiotics
Polye

来源

Streptomyces hygroscopicus

溶解度数据	体外研究: Ethanol : ≥ 50 mg/mL(66.94 mM) DMSO : 11.76 mg/mL(15.74 mM;ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C) ≥ means soluble, but saturation unknown. The molarity calculator equation Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) 质量浓度体积分子量计算重置 The dilution calculator equation Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 浓度体积浓度体积计算重置大包装询价 CAS NO 包装规格纯度数量单位名称 Product Name 联系人电话邮箱备注验证码大包装询价产品名称 * CAS NO * 规格需求 * 添加规格品牌需求时效 * 联系人 * 联系电话 * 公司/单位 * 联系邮箱 * 开票类型 * 收货地址 * 备注 * 在线留言电话： 400-086-2158 网址： www.med-life.cn Medlife公司关于我们联系我们法律声明加入 sitemap 支持与服务技术支持订购指南定制合成售后保障网络服务协议技术服务计算工具定制服务参考文献 CoA搜索(质检证书) 关注我们微信公众号微信咨询友情链接：生物云谷创赛中国 BaseSearch OALib 免费论文搜索引擎万方数据知识服务平台中国知网 PubMed 陌孚医药 PubChem 博飞美科试剂网创赛优选 medlife Copyright © 2025 陌孚医药 All rights reserved 未经授权禁止拷贝本站所有资料，如有违反，将追究法律责任。沪ICP备2023012080号 \| 沪公网安备31011402010657号站点地图隐私声明技术支持：库价化学在线留言标题验证码请填写图片中的字符留言内容 2403488663（全国经销商） 252984528（售后服务） 400-086-2158 扫码关注公众号首页分类购物车会员

溶解度数据

体外研究:
Ethanol : ≥ 50 mg/mL(66.94 mM)
DMSO : 11.76 mg/mL(15.74 mM;ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)
*≥ means soluble, but saturation unknown.