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Forskolin.

(Synonyms: 毛喉素; Coleonol; Colforsin; HL 362)

目录号: PC64047 纯度: ≥98%

Forskolin (Coleonol) 是一种有效的腺苷酸环化酶 (adenylate cyclase) 激活剂，对于 I 型腺苷酸环化酶，IC50 为 41 nM，EC50 为 0.5 μM。Forskolin 也是一种细胞内 cAMP 形成的诱导剂。

CAS No. :66575-29-9

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中文名称	Forskolin.
中文别名	佛司可林;福斯高林;毛喉萜;考福新;锦紫苏醇;腺苷酸环化酶激活剂;佛司可林(标准品);Forskolin 佛司可林;zzstandard 品牌毛喉素对照品;长春新碱;佛司可林 USP标准品;佛司可林标准品;佛司可林弗斯克林 Forskolin;佛司可林, 来源于毛喉鞘蕊花;佛司可林Forskolin;满萘喃酮;毛喉素;毛喉素(P);毛喉素(RG);佛司可林(福斯高林,毛喉萜,考福新,锦紫苏醇);弗司扣林,毛喉萜,福司柯林;弗斯可林;毛喉鞘蕊花提取物
英文名称	Forskolin
英文别名	FORSKOLIN;BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE;FORSKOHLIN;FORSKOLIN, COLEUS FORSKOHLII;COLEONOL;COLFORSIN;7BETA-ACETOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE;7BETA-ACETOXY-8,13-EPOXY-1ALPHA,6BETA,9ALPHA-TRIHYDROXY-LABD-14-EN-11-ONE;1H-Naphtho[2,1-b]pyran-1-one,5-(acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-,(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-;FORSKOLIN(P) PrintBack;FORSKOLIN(RG) PrintBack;Coleus Forskohlii Extract;[3H]-Forskolin;7β-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one;ForsLean;HL 362;L 75-1362B;NSC 357088;NSC 375489;(3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one;colforsina;colforsinum;colforsine;Boforsin;Colforsinum [Latin];Colforsine [French];Colforsina [Spanish];Coleonolk;Colforsin [USAN:INN];1F7A44V6OU;L
Cas No.	66575-29-9
分子式	C₂₂H₃₄O₇
分子量	410.50
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
详情描述	Forskolin (Coleonol) 是一种有效的腺苷酸环化酶 (adenylate cyclase) 激活剂，对于 I 型腺苷酸环化酶，IC50 为 41 nM，EC50 为 0.5 μM。Forskolin 也是一种细胞内 cAMP 形成的诱导剂。 Forskolin 诱导多种细胞类型的分化并激活孕烷 X 受体 (PXR) 和 FXR。 Forskolin 对心脏产生正性肌力作用，并具有血小板抗凝集和降压作用。Forskolin 也可诱导细胞自噬 (autophagy)。

生物活性	Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC₅₀ of 41 nM and an EC₅₀ of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
性状	Solid
IC50 & Target[1][2]	IC50: 41 nM (Adenylyl cyclase) EC50: 0.5 μM (Adenylyl cyclase)
体外研究(In Vitro)	Forskolin (Coleonol) is also a potent exosome biogenesis and/or secretion activator in prostate cancer (PC) cells. Forskolin (Fsk) is a naturally occurring diterpene isolated from Coleus forskholii, directly activates adenylyl cyclase (AC) through its catalytic subunit to increase intracellular levels of cyclic adenosine monophosphate (cAMP). Forskolin (Fsk) affects the proliferation of the human T-cell lines such as Kit 225 and MT-2. Forskolin treatment inhibits the proliferation of both Kit 225 and MT-2 cells in a dose-dependent manner with an IC50 equal to ~5 μM Fsk. Forskolin treatment (10-100 μM) increases cAMPi levels ~5- to 20-fold above basal levels, which reache maximum levels between 50-100 μM Forskolin. Medlife has not independently confirmed the accuracy of these methods. They are for
体内研究(In Vivo)	The Forskolin (Coleonol)-treated Mrp4 mice shows an increased number of Ki67-positive and cleaved caspase 3-positive ECs, a significant decrease in the amount of pericyte coverage, and a reduced number of empty sleeves. In pups exposed to hyperoxia (75% oxygen) from P7 to P12, the Mrp4 mice shows a significant increase in the unvascularized retinal area. The average blood glucose in the healthy rat group is 102.12±1.94 mg/dL, 101.25±3.56 for control group and 103±2.08 in forskolin group. The data shows that glucose levels at the end of the study are lower in forskolin group, with a significant difference according to the statistical tests applied (p=0.03). Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Terpenoids Diterp
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(243.61 mM;Need ultrasonic) 配制储存液

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Forskolin.

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