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11-Beta-hydroxyandrostenedione

(Synonyms: 4-Androsten-11β-ol-3,17-dione)

目录号: PC66977 纯度: ≥98%

11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) 是一种主要存在于肾上腺的类固醇 (11β-羟化酶存在于肾上腺组织，但在卵巢组织中不存在)。11-Beta-hydroxyandrostenedione 是一种 11β-羟基类固醇脱氢酶 (11βHSD) 同工酶抑制剂。随着 4-androstenedione 的增加，测量血浆 11-Beta-hydroxyandrostenedione 可以区分高雄激素血症的肾上腺或卵巢起源。11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) 是一种主要存在于肾上腺的类固醇 (11β-羟化酶存在于肾上腺组织，但在卵巢组织中不存在)。11-Beta-hydroxyandrostenedione 是一种 11β-羟基类固醇脱氢酶 (11βHSD) 同工酶抑制剂。随着 4-androstenedione 的增加，测量血浆 11-Beta-hydroxyandrostenedione 可以区分高雄激素血症的肾上腺或卵巢起源。

CAS No. :382-44-5

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中文名称	11-Beta-hydroxyandrostenedione
中文别名	4-雄烯-11β-醇-3,17-二酮;4-雄烯-11β-醇-3,17-二酮,标准品;咖啡酸,甲酯;氢化可松杂质1;11BETA-羟基-4-雄甾烯-3,17-二酮;11β-羟基雄甾-4-烯-3,17-二酮
英文名称	11-Beta-hydroxyandrostenedione
英文别名	Androst-4-ene-3,17-dione,11-hydroxy-, (11b)-;4-Androsten-11β-ol-3,17-dione;(8S,9S,10R,11S,13S,14S)-11-hydroxy-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthrene-3,17-dione;11beta-Hydroxyandrost-4-ene-3,17-dione;4-ANDROSTEN-11B-OL-3,17-DIONE;11beta-Hydroxyandrostenedione;11b-Hydroxyandrost-4-ene-3,17-dione;11β-Hydroxy-4-androstene-3,17-dione;4-Androsten-11beta-ol-3,17-dione;Androst-4-ene-3,17-dione-11beta-ol;U 2826;(11beta)-11-Hydroxyandrost-4-ene-3,17-dione;11-Beta-hydroxyandrostenedione
Cas No.	382-44-5
分子式	C₁₉H₂₆O₃
分子量	302.41
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	11-Beta-hydroxyandrostenedione (4-Androsten-11β-ol-3,17-dione) is a steroid mainly found in the the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue). 11-Beta-hydroxyandrostenedione is a 11β-hydroxysteroid dehydrogenase (11βHSD) isozymes inhibitor. As 4-androstenedione increases, measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

In order to establish that this conversion is catalysed by the lyase activity of CYP17A1, 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) is assayed within the LNCaP cell line. Upon the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF and 21dE are in fact metabolised to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

The plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high in 21-hydroxylase deficiency, Cushings syndrome, and hyperandrogenism of adrenal origin, and very low in congenital 11-hydroxylase deficiency and adrenal insufficiency. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Steroids

溶解度数据	体外研究: DMSO : 100 mg/mL(330.68 mM;Need ultrasonic) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

11-Beta-hydroxyandrostenedione

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