Reserpine|50-55-5|(利血平)-陌孚医药/Medlife

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Reserpine (Synonyms: 利血平)

目录号: PC62882 纯度: ≥99%

CAS No. :50-55-5

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中文名称	Reserpine
中文别名	利血平;血安平;蛇根碱;白杨素;大青叶提取物;拉米夫定;利血平 EP标准品;利血平 USP标准品;利血平标准品;利血平（标准品）;利血平, 来源于萝芙木属植物;利血平植物提取物,标准品,对照品;利血平,分析标准品;利血平标准品(JP);萝芙木提取物;印度穆库尔没药（没药甾酮）;利舍平;蛇根草素;寿比安;利血平，利舍平，蛇根碱，血安平
英文名称	Reserpine
英文别名	Reserpine;reserpine crystalline;3,4,5-Trimethoxybenzoyl methyl reserpate;Reserpine base;Resperine;Reserpine;methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate;RESERPINE(P) PrintBack;[3H]-Reserpine;Apoplon;Crystoserpine;Eskaserp;Hiserpia;methyl reserpate 3,4,5-trimethoxybenzoic acid ester;Raunervil;Raupasil;Raused;Rausedil;Reserpoid;Rivasin;Sandril;Serpalan;Serpanray;Serpasil;Serpivite;(3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;3b,20a-Yohimban-16b-carboxylic acid, 18b-hydroxy-11,17a-dimethoxy- methyl ester 3,4,5-trimethoxybenzoate (ester)(8CI);3b,20a-Yohimban-16b-carboxylic acid,18b-hydroxy-11,17a-dimethoxy-, methyl ester, 3,4,5-trimethoxybenzoate(6CI);Benz[g]indolo[2,3-a]quinolizine, yohimban-16-carboxylic acid deriv.;(-)-Reserpine;11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acidmethyl ester;Anquil;Banasil;Bioserpine;Carpacil;Deserpine;ENT 50146;Elserpine;Eserpine;Hiposerpil;Kitine;Lemiserp;Loweserp;Mayserpine;Methylreserpate 3,4,5-trimethoxybenzoate (ester);NSC 237659;NSC 59272;Quiescin;Rau-sed;Raucap;Raulen;Raurine;Rausedyl;Rausingle;Rauwasedin;Resercaps;Resercen;Reserlor;Reserpamed;Reserpex;Reserpic acid methyl ester 3,4,5-trimethoxybenzoate (ester);Reserpil;Resine;Respital;Restran;Riserpa;Roxinoid;Sedaraupin;Sedserp;Serfin;Serolfia;Serp-AFD;Serpaloid;Serpasil Serpasol;Serpasil premix;Serpasol;Serpate;Serpen;Serpentina;Serpicon;Serpiloid;Serpine;Serpine (pharmaceutical);Serpipur;Sertabs;Sertina;T-Serp;Temposerpine;Triserpin;Vio-Serpine;Alserin;Hypersil;Enipresser;Helfoserpin;Eskaserpine;Rauserpine;Purserpine;Mephaserpin;Reserpanca;Maviserpin;Austrapine;Ascoserpina;Reserpal;Reserjen;Rautrin;Rauserpol;Raudixoid;Neoserp;Idsoserp;Hypersine;Escaspere;Apsical;A
Cas No.	50-55-5
分子式	C₃₃H₄₀N₂O₉
分子量	608.68
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性

Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2).

性状

Solid

IC50 & Target[1][2]

VMAT2

体外研究(In Vitro)

Reserpine is an inhibitor of the vesicular monoamine transporter 2 (VMAT2). Reserpine displays a significant effect on the density of dopamine D1 receptors (F2,12=8.81, p<0.01) in the rat striatum. The affinity (Kd) for the dopamine D1 and D2 receptors during withdrawal from acute and chronic administration of reserpine is not change. IC50 values of 43.9 and 54.9 μM are obtained after 1 day of treatment with Reserpine in JB6 P+ and HepG2-C8 cells, respectively. Reserpine induces luciferase activity in a dose-dependent manner at concentrations ranging from 5 to 50 μM, and no significant induction is observed at concentrations lower than 5 μM. Results demonstrate that Reserpine (2.5 to 10 μM) also increases the protein expression of Nrf2, HO-1, and NQO1. Reserpine at concentrations of 2.5 to 10 μM decreases the mRNA expression of DNMT1, DNMT3a, and DNMT3

体内研究(In Vivo)

Withdrawal (48 h) from chronic (14-day) but not acute Reserpine administration in a dose of 0.2 mg/kg i.p. produces a significant reduction of the immobility time (F2,18=3.68, p<0.05), but increases the climbing time (F2,18=4.48, p<0.02), and does not change the swimming time (F2,18=1.78; NS) in the forced swim test (FST) in rats. Reserpine at a dose of 5 mg/kg body weight produces significant increase in the urinary excretion profile of vanillylmandelic acid (VMA) compare to control animals. The amount of 5-hydroxyindoleacetic acid (5-HIAA) excreted in animals treated with Reserpine is found to be more than in the control.Dose dependent hypotension is observed with Reserpine. Reserpine at doses of 0.5, 1, 5, 10 and 15 μg/kg produce significant (p<0.01) reduction in blood pressure compare to control.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Alkaloids
Piperid

来源

Plants
other fami

溶解度数据	体外研究: DMSO : 25 mg/mL(41.07 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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