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Hygromycin B

(Synonyms: 潮霉素B; Hygrovetine)

目录号: PC61242 纯度: ≥98.0%

Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。

CAS No. :31282-04-9

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中文名称	Hygromycin B
中文别名	潮霉素 B;潮霉素B 来源生物发酵;Hygromycin B 潮霉素B;潮霉素 B (水合物) 标准品;潮霉素B 标准品;潮霉素B 来源于吸水链霉菌;潮霉素B（干粉）;潮霉素B,BR;潮霉素B、潮霉素B药;潮霉素B溶液;湿霉素乙;潮霉素 B 来源于吸水链霉菌;潮霉素B;潮霉素
英文名称	Hygromycin B
英文别名	Hygromycin B;O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-o-beta-D-talopyranosyl-(1-5)-2-deoxy-N3-methyl-D-streptamine;Hygromycin B solution from Biological Fermentation;Hygromycin B solution;Hygromycin B powder;Hygrovetine;antihelmycin;Destomycin A;Hyaromycin B;hydromycinb;HYGROGOLD(TM);Hygromix;hygromix2.4;hygromix-8;Hygromycin B, Streptomyces hygroscopicus, High Purity, in DI Water;Hygrovetin
Cas No.	31282-04-9
分子式	C₂₀H₃₇N₃O₁₃
分子量	527.52
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	Hygromycin B是抑制原核和真核细胞的氨基糖苷类抗生素。

生物活性	Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.
性状	Solid
IC50 & Target[1][2]	Aminoglycoside

体外研究(In Vitro)

Hygromycin B, an aminocyclitol antibiotic that strongly inhibits both 70S and 80S ribosomes, is synthesized by Streptomyces hygroscopicus. Hygromycin B at 0.38 mM concentration completely halts yeast cell growth in rich media, presumably by preventing protein synthesis by cytoplasmic ribosomes. Polypeptide synthesis in cell-free extracts from rabbit reticulocytes, wheat germ and yeast is strongly blocked by low concentrations ofhygromycin B. The antibiotic inhibits peptide chain elongation by yeast polysomes by preventing elongation factor EF-2-dependent translocation. The inhibition of translocation by hygromycin B might result from the stabilization of peptidyl-tRNA bound to the ribosomal acceptor site.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Hygromycin B inhibits protein synthesis by blocking ribosomal translocation without causing significant misreading in vivo. Constitutive expression of the bacterial hyg gene in transgenic mice in vivo confers resistance to hygromycin B.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Antibiotics
Other

来源

Escherichia coli

溶解度数据	体外研究: DMSO : 100 mg/mL(189.57 mM;ultrasonic and warming and heat to 60°C) H₂O : 50 mg/mL(94.78 mM;Need ultrasonic) 配制储存液

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Hygromycin B

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