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Angiotensin II human

(Synonyms: 血管紧张素Ⅱ; Angiotensin II; Ang II; DRVYIHPF)

目录号: PC61642 纯度: ≥99%

Angiotensin II (Angiotensin II) 是一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。

CAS No. :4474-91-3

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中文名称	Angiotensin II human
中文别名	血管紧张素II;血管紧张素Ⅱ;[Ile5]-血管紧缩素 2;人血管紧张素II;人血管紧张素II相对分子质量标准物质;人血管紧张肽 II<电离质谱校准物>;血管紧张素II,人;血管紧张肽 II;血管紧张素2;血管紧张肽酰胺;增加压素;增血压素,HYPERTENSIN;人血管紧张肽II;醋酸血管紧张素II
英文名称	Angiotensin II human
英文别名	Angiotensin II,5-L-isoleucine-;Angiotensin Acetate II;Angiotensin II;Angiotensin II, Ang II;Angiotensin II, human;Human angiotension II Relative Molecular Weight;[ILE5]-ANGIOTENSIN 2;[Ile5]angiotensin II;Ang II;Angiotensin Ⅱ, huMan;ANGIOTENSIN-2;angiotensinii(mouse);ANTI-ANGIOTENSIN II;Asp1-Arg2-Val3-Tyr4-Ile5-His6-Pro7-Phe8;Asp-Arg-Val-Tyr-Ile-His-Pro-Phe;DRVYIHPF;H2N-DRVYIHPF-COOH;H-DRVYIHPF-OH;HUMAN;human angiotensin II;Hypertensin;Hypertensin II;ile(5)-angiotensini;TY-10721;Alanine,N-[1-[N-[N-[N-[N-(N2-L-a-aspartyl-L-arginyl)-L-valyl]-L-tyrosyl]-L-isoleucyl]-L-histidyl]-L-prolyl]-3-phenyl-,L- (6CI,7CI);10: PN: WO0212471 SEQID: 17 unclaimed sequence;12: PN: WO0239997 SEQID: 17unclaimed sequence;17: PN:US6610497 SEQID: 17 unclaimed sequence;17: PN: US6884771 SEQID: 17 unclaimedsequence;17: PN: US6989363 SEQID: 17 unclaimed sequence;1:PN: CN1706502 PAGE: 2 claimed sequence;1: PN: US6022696 SEQID: 2 unclaimedsequence;1: PN: WO0002905 SEQID: 1 claimed protein;Angiotensin II human;Angiotensin II (mouse);Angiotensin II (human);Giapreza;5-Isoleucine-angiotensin II;5-L-Isoleucineangiotensin II;Ile(5)-angiotensin II;1-8-Angiotensin I;isoleucine(5)-angiotensin II;CZGUSIXMZVURDU-JZXHSEFVSA-N;M089EFU921;Isoleucine5-angiotensin II;Angiotensin II, ile(5)-;Angiotensin ii [INN:JAN];Angiotensin II (USAN)
Cas No.	4474-91-3
分子式	C₅₀H₇₁N₁₃O₁₂
分子量	1046.18
包装储存	Sealed and stored away from moisture and light, under nitrogen；Powder； -80°C； 2 years; -20°C； 1 ye
详情描述	Angiotensin II (Angiotensin II) 是一种血管收缩剂，是肾素/血管紧张素系统的主要生物活性肽。 Angiotensin II human 在调节人类血压中起着核心作用，主要通过血管紧张素 II 与 G 蛋白偶联受体 (GPCRs)、血管紧张素II 1型受体 (AT1R) 和血管紧张素II 2型受体 (AT2R) 之间的相互作用来介导。 Angiotensin II human 刺激交感神经刺激，增加醛固酮生物合成和肾脏活动。 Angiotensin II human 诱导血管平滑肌细胞生长，增加成纤维细胞中 I 型和 III 型胶原的合成，导致血管壁和心肌增厚，并导致纤维化。Angiotensin II human 也诱导细胞凋亡 (apoptosis)。 Angiotensin II human 通过 LOX-1 依赖的氧化还原敏感途径诱导内皮细胞毛细血管形成。

生物活性

Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

性状

Solid

IC50 & Target[1][2]

AT1 Receptor
AT2 Receptor

体外研究(In Vitro)

Most of the known actions of Angiotensin II (Ang II) are mediated by AT1 receptors, the AT2 receptor contributes to the regulation of blood pressure and renal function
. Angiotensin II raises blood pressure (BP) by a number of actions, the most important ones being vasoconstriction, sympathetic nervous stimulation, increased aldosterone biosynthesis and renal actions. Other Angiotensin II actions include induction of growth, cell migration, and mitosis of vascular smooth muscle cells, increased synthesis of collagen type I and III in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. These actions are mediated by type 1 Ang II receptors (AT1).
Angiotensin II (1 nM) induces the expression of LOX-1 and VEGF and enhances capillary formation from human coronary endothelial cells in Matrigel assay. Angiotensin II -mediated expre

体内研究(In Vivo)

Angiotensin II human (5 mL of 1 nM; intraperitoneal injection; 200-250 g Sprague-Dawley rats) induces a significant neutrophil recruitment that was maximal at 4 hours and had resolved by 24 hours.
To distinguish the AT1 receptor population that is critical for the pathogenesis of hypertension, osmotic minipumps are implanted s.c. into each animal to infuse Angiotensin II (1000 ng/kg/min) continuously for 4 weeks. Angiotensin II causes hypertension by activating AT1 receptors in the kidney promoting sodium reabsorption.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Sealed and stored away from moisture and light, under nitrogen；Powder； -80°C； 2 years; -20°C； 1 ye

ClinicalTrial

SequenceShortening

DRVYIHPF

Sequence

Asp-Arg-Val-Tyr-Ile-His-Pro-Phe

结构分类

Others

溶解度数据	体外研究: DMSO : 100 mg/mL(95.59 mM;Need ultrasonic) H₂O : 50 mg/mL(47.79 mM;Need ultrasonic) 配制储存液

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Angiotensin II human

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