D-Galactose is a natural aldohexose and C-4 epimer of glucose.
性状
Solid
IC50 & Target[1][2]
Human Endogenous Metabolite
体外研究(In Vitro)
Galactose is important for the survival and virulence of bacteria. In Escherichia coli galactose is utilized by the Leloir pathway. Two anomers of d-galactose are used for different purposes, α-d-galactose as a carbon source and β-d-galactose for induction of UDP-galactose synthesis for biosynthetic glycosylation.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Chronic D-galactose exposure induces neurodegeneration by enhancing caspase-mediated apoptosis and inhibiting neurogenesis and neuron migration in mice, as well as increasing oxidative damage. In addition, D-galactose-induced toxicity in mice is a useful model for studying the mechanisms of neurodegeneration and neuroprotective drugs and agents. D-galactose given by oral route causes cognitive impairments in rats which are accompanied by oxidative damage. Cognitive impairments is observed in the open-field test in the 4th and 6th weeks after d-gal administration, as well as an impairment in spatial memory in the radial maze test after the 6th week of d-gal administration.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transport.
储存方式
Powder; -20°C; 3 years; 4°C; 2 years;
ClinicalTrial
结构分类
Saccharides
来源
Plantsother fami
溶解度数据
体外研究:H2O : 62.5 mg/mL(346.91 mM;ultrasonic and warming and heat to 60°C)DMSO : 50 mg/mL(277.53 mM;Need ultrasonic)配制储存液