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Artemisitene (Synonyms: 青蒿烯)
目录号: PC64345 纯度: ≥98%
CAS No. :101020-89-7
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中文名称
Artemisitene
中文别名
青蒿烯;(4S,4'S)-2,2'-(环戊烷-1,1-二基)-双(4-苄基-4,5-二氢噁唑);Artemisiten标准品;青蒿素(甲基青蒿素);脱氢青蒿素;甲基黄花蒿素;青蒿烯 (甲基青蒿素)
英文名称
Artemisitene
英文别名
3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6-dimethyl-9-methylene-, (3R,5aS,6R,8aS,12S,12aR)-;Artemisitene;3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one,octahydro-3,6-dimethyl-9-methylene-,...;Dehydroqinghaosu;Methyl Artemisinin;ArteMisitene (Methyl ArteMisinin);(3R,5aS,6R,8aS,12S,12aR)-Octahydro-3,6-diMethyl-9-Methylene-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
Cas No.
101020-89-7
分子式
C15H20O5
分子量
280.32
包装储存
Powder; -20°C; 3 years; 4°C; 2 years;
生物活性
Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability.
性状
Solid
体外研究(In Vitro)
Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature or refrigerated transport.
储存方式
Powder; -20°C; 3 years; 4°C; 2 years;
结构分类
Terpenoids
Sesqui
来源
Plants
溶解度数据
体外研究:
DMSO : ≥ 100 mg/mL(356.74 mM)
*≥ means soluble, but saturation unknown.
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1:一般建议:溶解度为Medlife测试数据,可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异,仅做参考,具体以实验方案为准。

2:储存条件:粉末-20°C一般情况可以保存3年,溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异,请细致阅读产品信息,并辅助参考相关文献描述。

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