Thapsigargin|67526-95-8|(毒胡萝卜素)-陌孚医药/Medlife

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Thapsigargin (Synonyms: 毒胡萝卜素)

目录号: PC64050 纯度: ≥99%

CAS No. :67526-95-8

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中文名称	Thapsigargin
中文别名	毒胡萝卜素;毒胡萝卜素, 来源于毒胡萝卜
英文名称	Thapsigargin
英文别名	Thapsigargin;THAPSIGARGIN(RG);Thapsigargin,(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-;Pamoic acid disodium salt;rcrawastenumberu217;sesquiterpene lactone;sesquiterpene lactone tetraester;Thallium mononitrate;THALLIUM NITRATE;thallous;THALLOUS NITRATE;thallous nitrate TlNO3,orthorhombic;Thapsigargin,(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yloctanoate;CHEBI:9516;CHEMBL96926;UNII-Z96BQ26RZD;Z96BQ26RZD;[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-acetyloxy-4-butanoyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-2-oxo-4,5,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-7-yl] octanoate;Azuleno[4,5-b]furan octanoic acid deriv.;(-)-Thapsigargin;MFCD00083511
Cas No.	67526-95-8
分子式	C₃₄H₅₀O₁₂
分子量	650.75
包装储存	-20°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

生物活性	Thapsigargin, an endoplasmic reticulum (ER) stress inducer, is an inhibitor of microsomal Ca-ATPase. Thapsigargin efficiently inhibits coronavirus (HCoV-229E, MERS-CoV, SARS-CoV-2) replication in different cell types.
性状	Solid
IC50 & Target[1][2]	Ca-ATPase
体外研究(In Vitro)	Thapsigargin (0.001-?1 μM; for 2 and 4 days) arrests cell proliferations in MH7A human rheumatoid arthritis synovial cells in a time- and dose-dependent manner. Thapsigargin (0.001-?1 μM; for 2 and 4 days) induces cell apoptosis in MH7A cells in a time- and dose-dependent manner. Thapsigargin (0.001-?1 μM; for 2 and 4 days) impairs mTOR activity and leads to cyclin D1 expressions in MH7A cells. Thapsigargin inhibits Ca entry into human neutrophil granulocytes. Thapsigargin inhibits the carbachol-evoked [Ca]i-transients with (IC50=0.353 nM) or without (IC50=0.448 nM) a KCl-prestimulation, but an additional small component, with a much lower sensitivity (IC50=4814 nM), is observed in the absence of a KCl-prestimulation. In contrast, the KCl-evoked [Ca]i-transients displayed only one component with a very low sensitivity to Thaps
体内研究(In Vivo)	Thapsigargin (Injection; 0.25 ug/g, 0.5 ug/g and 1 ug/g; 24 hours) significant increases of 2 to 5-fold in chemokine and pro-inflammatory expression. Thapsigargin is more sensitive to inducing a systemic immune response.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. Animal Mod
运输条件	Room temperature or refrigerated transport.
储存方式	-20°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；
结构分类	Terpenoids Diterp
来源	Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(153.67 mM;Need ultrasonic) H₂O : 25 mg/mL(38.42 mM;Need ultrasonic) 配制储存液

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