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Naringin Dihydrochalcone.

(Synonyms: 柚皮苷二氢查尔酮; Naringin DC)

目录号: PC58935 纯度: ≥99%

Naringin Dihydrochalcone是由柚皮苷衍生的人造甜味剂。柚皮苷是从番茄，葡萄柚和许多其他柑橘类水果中获得的主要黄烷酮糖苷。柚皮素表现出抗氧化，抗炎和抗细胞凋亡等生物活性。Naringin 可抑制 NF-κB 信号通路。Naringin Dihydrochalcone是由柚皮苷衍生的人造甜味剂。柚皮苷是从番茄，葡萄柚和许多其他柑橘类水果中获得的主要黄烷酮糖苷。柚皮素表现出抗氧化，抗炎和抗细胞凋亡等生物活性。Naringin 可抑制 NF-κB 信号通路。

CAS No. :18916-17-1

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中文名称	Naringin Dihydrochalcone.
中文别名	柚皮苷二氢查尔酮;柚皮甙二氢查尔酮;柚皮苷二氢查耳酮;4-（2,4-二氟苯基）哌啶;柚苷二氢查耳酮;柚皮甙二氢查尔酮 Naringin dihydrochalcone;柚皮甙二氢查尔酮,Naringin dihydrochalcone,植物提取物,标准品,对照品;柚皮甙二氢查尔酮对照品;柚皮苷二氢查尔酮标准品;柚皮苷二氢查尔酮(柚皮甙二氢查尔酮);柚皮苷二氢查尔酮对照品;高级糖精;西仑吉肽;柚苷二氢查尔酮;柚皮甙二氢查耳酮;柚皮甙二氢査尔酮;柚皮甙二氢查尔酮.柚苷二氢;柚皮苷二氢查尔酮(标准品)
英文名称	Naringin Dihydrochalcone
英文别名	Naringin dihydrochalcone;NARINGIN DIHYDOROCHALCONE;NAGINGINDIHYDROCHALCONE;Naringin DC;NARINGINDIHYDROHALCONE;1-[4-[[2-O-(6-Deoxy-L-mannopyranosyl)-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-1-propanone;Senior saccharin;2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl);Naringin dihydrochal;Naringin Dihydrochalcone(Naringin DC);Naringin-dihydro-chalkon;2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-;Senior saccharin;ranosyl)- β-D-glucopyranosyl]oxy]-;1-Propanone, 1-[4-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)-;1-[4-[(2S,3R,4S,5R,6R)-4,5-Dihydroxy-6-(hydroxymethyl)-3-[(2S,3S,4R,5R,6S)-3,4,5-trihydroxy-6-methyl
Cas No.	18916-17-1
分子式	C₂₇H₃₄O₁₄
分子量	582.55
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.
性状	Solid
IC50 & Target[1][2]	NF-κB

体外研究(In Vitro)

Naringin suppresses NF-κ B signaling pathway activation. Naringenin inhibits high glucose-induced proliferation, inflammatory reaction and oxidative stress injury in HBZY-1 cells. Naringin inhibits AGS cancer cell proliferation in a dose- and time-dependent manner. Phosphorylation of PI3K and its activated downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin induces autophagic cell death in AGS cells. Naringin activated the autophagy related protein in AGS cells. Naringin protects PC12 cells from 3-NP neurotoxicity. The lactate dehydrogenase release is decreased upon naringin treatment in 3-NP-induced PC12 cells. Naringin treatment enhances the antioxidant defense by increasing the activities of enzymatic antioxidants and the level of reduced glutathione.Medlife has no

体内研究(In Vivo)

Treatment with naringin significantly alleviates renal injury in diabetic rats and increases diabetic rats body weight significantly. Administration of naringin effectively alleviates the collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin could result in decreased levels of ROS and MDA and increased activities of SOD and GSH-Px. Oral administration of naringin significantly improves the learning and memory abilities. Naringin significantly enhances insulin signaling pathway.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Flavonoids
Dihydr

来源

Plants
other fami

溶解度数据	体外研究: DMSO : ≥ 100 mg/mL(171.66 mM) *≥ means soluble, but saturation unknown. 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Naringin Dihydrochalcone.

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