Calcitriol.|32222-06-3|(骨化三醇; 1,25-Dihydroxyvitamin D3)-陌孚医药/Medlife

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Calcitriol. (Synonyms: 骨化三醇; 1,25-Dihydroxyvitamin D3)

目录号: PC61654 纯度: ≥99%

CAS No. :32222-06-3

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中文名称	Calcitriol.
中文别名	骨化三醇;钙三醇;罗钙全;二羟胆钙化醇;(5Z,7E)-(1S,3R)-9,10-开环胆甾-5,7,10(19)-三烯-1,3,25-三醇;1,25-二羟基维生素D3;1,25-二羟维生素D3;1α,25-二羟基维生素 D3;二羟基维生素D3;骨化三醇 Calcitriol;骨化三醇 EP标准品;骨化三醇(SH);骨化三醇(治骨质疏松);骨化三醇-D6;骨化三醇标准品;1,25二羟基维生素D3;1α,25-二羟维生素D3 标准品;1Α,25-羟胆钙化醇;骨化三醇二羟胆钙化醇(5Z,7E)-(1S,3R)-9,10-开环胆甾-5,7,10(19)-三烯-1,3,25-三醇;1α,25-二羟基维他命D3;1,25-二羟基胆钙化醇
英文名称	Calcitriol
英文别名	1A,25-dihydroxycholecalciferol;Vitamin D3, 1a,25-Dihydroxy-;1alpha,25-Dihydroxyvitamin D3;1a,25-Dihydroxyvitamin;1alpha,25-dihydroxycholecalciferol;(5z,7e)-(1s,3r)-9,10-secocholesta-5,7,10(19)-triene-1,3,25-triol;1α,25-dihydroxycholecalciferol;Calcitriol;(1R,3S,Z)-5-((E)-2-((1R,3AS,7aR)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)-4-methylenecyclohexane-1,3-diol;1,25-Dihydroxyvitamin D3;1α,25-Dihydroxyvitamin D3;1α,25-Dihydroxyvitamin D3 solution;Rocalirol;(1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;Vitamin D3;1,25-Dihydroxycholecalciferol
Cas No.	32222-06-3
分子式	C₂₇H₄₄O₃
分子量	416.64
包装储存	-20°C, Keep In Dark, stored under nitrogen；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

生物活性	Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.
性状	Solid
IC50 & Target[1][2]	Human Endogenous Metabolite

体外研究(In Vitro)

Calcitriol exerts antiproliferative effects on cervical cancer cells in vitro. Cells decrease by 12.8% when treated with 100 nM Calcitriol for 6 days, compare with control. Inhibition of cell proliferation becomes more pronounced with the increase in Calcitriol concentration. The decrease is 26.1% and 31.6% for 200 and 500 nM Calcitriol, respectively. Treatment with Calcitriol for 72 h induces an evident accumulation of cells in the G1 phase, with approximately 66.18% in 200 nM and 78.10% in 500 nM, compare with the control (24.36%).Calcitriol treatment significantly decreases HCCR-1 protein expression compare with the control in a time- and dose-dependent manner. Calcitriol significantly increases ERα mRNA in a dose dependent manner with an EC50 of 9.8×10 M.Medlife has not independently confirmed the accur

体内研究(In Vivo)

Chronic treatment with Calcitriol (150 ng/kg per day for 4.5 months) improves the relaxations (pD2: 6.30±0.09, Emax: 68.6±3.9% in Calcitriol-treated OVX, n=8). Renal blood flow in OVX rats is reduced in both kidneys, and the flow is restored by Calcitriol treatment. The increased expression of COX-2 and Thromboxane-prostanoid (TP) receptor in OVX rat renal arteries is reduced by chronic calcitriol administration. High- and low-dose Calcitriol treatment significantly decreases the systolic blood pressure (SBP) in the fructose-fed rats by 14±4 and 9±4 mmHg, respectively, at Day 56. High-dose Calcitriol treatment (20 ng/kg per day) significantly increases serum ionized calcium level (1.44±0.05 mmol/L) compare with the other groups.Medlife has not independently confirmed the accuracy of these methods. They ar

运输条件

Room temperature or refrigerated transport.

储存方式

-20°C, Keep In Dark, stored under nitrogen；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

ClinicalTrial

结构分类

Others

溶解度数据	体外研究: DMSO : 110 mg/mL(264.02 mM;Need ultrasonic) Ethanol : 100 mg/mL(240.02 mM;Need ultrasonic) 配制储存液

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产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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