Nicotiflorin|17650-84-9|-陌孚医药/Medlife

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Nicotiflorin

目录号: PC58707 纯度: ≥99%

CAS No. :17650-84-9

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中文名称	Nicotiflorin
中文别名	莰菲醇-3-O-芸香糖苷;山奈酚-3-O-芸香糖苷;山柰酚-3-O-芸香糖苷;山奈酚-3-O-芸香糖苷,Kaempferol-3-O-Rutinoside,植物提取物,标准品,对照品;山柰酚-3-O-芸香糖苷(AS);山柰酚-3-O-芸香糖苷(标准品);山柰酚-3-O-芸香糖苷（烟花苷）;烟花甙;烟花苷;山柰酚-3-O-芸香糖苷(烟花苷,莰菲醇-3-O-芸香糖苷,莰非醇-3-O-芸香糖苷);莰菲醇 3-O-芸香糖苷;莰非醇-3-O-芸香糖苷;山柰酚-3-O-芸香糖苷, 来源于红花;山奈酚-3-O-芸香糖苷,又名莰菲醇-3-O-芸香糖苷;烟花苷,莰菲醇-3-O-芸香糖苷,莰非醇-3-O-芸香糖苷
英文名称	Nicotiflorin
英文别名	4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-;4H-1-Benzopyran-4-one,3-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5,7-dihydro...;5,7-dihydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one;KaeMpferol-3-O-rutinosid, froM CarthaMus tinctorius;KAEMPFEROL-3-O-RUTINOSIDE;KAEMPFEROL-3-O-RUTINOSIDE(AS) PrintBack;Kaempferol-3-Rutinoside;NICOTIFLORIN;Kaempferol 3-O-rutinose;Nicotiflorine;NICOTIFLOROSIDE;3,4′,5,7-Tetrahydroxyflavone 3-rhamnoglucoside;Kaempferol 3-O-β -rutinoside;Nicotifiorin;3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Kaempferol 3-rhamnoglucoside;Kaempferol 3-rutinoside;[ "Kaempferol 3-rutinoside" ];Nicotoflorin;Kaempfeol-3-O-rutinoside;Aempferol-3-O-rutinoside;Kaempferol-3-O-rutinosid;Nictoflorin (incorr;Nictoflorin;Kaempferol-3-O-beta-rutinoside;Kaempferol 3-O-rutinoside;4056D20K3H;kaempferol 3-O-(6''-O-alpha-L-rhamnopyranosyl)-beta-D-glucopyranoside;3-rutinosylkaempferol;MLS000563045;MEGxp0_000024;Kaempferol 3-O-beta-rutinoside;Kaempferol 3-O-;A -rutinoside
Cas No.	17650-84-9
分子式	C₂₇H₃₀O₁₅
分子量	594.52
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Nicotiflorin is a flavonoid glycoside extracted from a traditional Chinese medicine Carthamus tinctorius. Nicotiflorin shows potent antiglycation activity and neuroprotection effects.
性状	Solid
IC50 & Target[1][2]	Antiglycation
体外研究(In Vitro)	For primarily cultured neurons suffered 2 h hypoxia followed by 24 h reoxygenation, nicotiflorin significantly attenuates cell death and reduces LDH release. Morphological observation also directly confirms its protective effect on neuron. After total 4 h hypoxia and 12 h reoxygenation, eNOS activity, mRNA and protein levels in the primarily cultured rat cerebral blood vessel endothelial cells treated with nicotiflorin (25-100 g/mL) 2 h after onset of hypoxia are significantly higher than eNOS activity, mRNA and protein levels in the pure H-R cells and also higher than eNOS activity, mRNA and protein levels in cells cultured under normoxic conditions.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	At doses of 2.5, 5 and 10 mg/kg, nicotiflorin administered immediately after the onset of ischemia markedly reduces brain infarct volume and neurological deficits. Nicotiflorin (2.5-10 mg/kg) administered after onset of ischemia markedly reduces brain infarct volume by 24.5-63.2% and neurological deficits.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Flavonoids Flavon
来源	Plants

溶解度数据	体外研究: DMSO : 250 mg/mL(420.51 mM;Need ultrasonic) 配制储存液

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