Isoorientin|4261-42-1|(异荭草素; Homoorientin)-陌孚医药/Medlife

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Isoorientin (Synonyms: 异荭草素; Homoorientin)

目录号: PC58379 纯度: ≥98%

CAS No. :4261-42-1

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中文名称	Isoorientin
中文别名	异荭草苷;异荭草素;4-甲基伞形酮-β-D-葡糖苷酸二水合物;zzstandard 品牌异荭草苷对照品;异荭草苷异荭草素;异荭草苷(P);异荭草苷(SH);异荭草苷(标准品);异荭草苷（异荭草素）;异荭草苷(异荭草素)(P);异荭草苷Homoori entin;异荭草苷标准品对照品;异荭草素,Isoorientin,植物提取物,标准品,对照品;异红草素;异荭草苷(异荭草素,异荭草苷 ,异荭草素);异荭草苷,Isoorientin,对照品,标准品,中草药;异荭草苷,异荭草素;异荭草苷,异荭草素,Homoorientin,植物提取物,标准品,对照品;木犀草素6-C-β-D-葡萄糖苷
英文名称	Isoorientin
英文别名	Isoorientin;Homoorientin;(1S)-1,5-anhydro-1-[2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-D-glucitol;Luteolin-6-C-glucoside;4H-1-Benzopyran-4-one,2-(3,4-dihydroxyphenyl)-6-b-D-glucopyranosyl-5,7-dihydroxy-;HOMOORIENTIN(ISOORIENTIN)(P) PrintBack;HOMOORIENTIN(ISOORIENTIN)(SH) PrintBack;Lespecapitoside;Luteolin6-C-β-D-glucoside,Luteolin6-C-glucoside;Luteolin 6-C-β-D-glucoside;Luteolin 6-C-glucoside;Luteolin-6-C-beta-D-glucoside;A37342TIX1;2-(3,4-Dihydroxyphenyl)-6-beta-D-glucopyranosyl-5,7-dihydroxy-4H-1-benzopyran-4-one;Homoori-entin;2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one;Lespecapitioside;MLS002473101;Luteolin 6-C-beta-D-glucoside;Isoorientin, analytical standard;Luteolin 6-C-bet.-D-glucoside
Cas No.	4261-42-1
分子式	C₂₁H₂₀O₁₁
分子量	448.38
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Isoorientin is a potent inhibitor of COX-2 with an IC₅₀ value of 39 μM.
性状	Solid
IC50 & Target[1][2]	COX-2 39 μM (IC50)

体外研究(In Vitro)

Isoorientin is a Selective Inhibitor of Cyclooxygenase-2 (COX-2) from the Tubers of Pueraria tuberosa. PANC-1 and PATU-8988 cells are grown for 24 hours in the presence of Isoorientin (0, 20, 40, 80, and 160 μM), and a CCK8 solution is added. The cell viability decreases significantly at the concentrations of 20, 40, 80, and 160 μM. After the cells are cultured with Isoorientin (0, 20, 40, 80, and 160 μM for PANC-1; 0, 20, 40, 80, 160, and 320 μM for PATU-8988) for 24 hours, the expression of p-AMPK and AMPK is assessed by Western blotting. After the Isoorientin treatment, the p-AMPK expression is increased. Then, in the shRNA group, the concentration of 80 μM is used to detect the effects of Isoorientin. The expression levels of AMPK and p-AMPK are much lower in the shRNA group than in the wild-type PC cells (WT) and the group that is transfected with a negative control lenti

体内研究(In Vivo)

Animals treated with Isoorientin at 10?mg/kg and 20?mg/kg body weight have a statistically significant reduction in paw edema, with a mean peak thickness of 1.19±0.05?mm and 1.08±0.04?mm, respectively. This indicated that Isoorientin significantly attenuates paw edema compared with the control group.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Flavonoids
Flavon

来源

Plants
other fami

溶解度数据	体外研究: DMSO : ≥ 100 mg/mL(223.03 mM) *≥ means soluble, but saturation unknown. 配制储存液

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2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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