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产品总数：61471
| 中文名称 |
Isoliquiritigenin
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|---|---|
| 中文别名 |
异甘草素;(E)-1-(2,4-二羟基苯基)-3-(4-羟基苯基)-2-丙烯-1-酮;2',4,4'-三羟基查耳酮;Isoliquiritigenin 异甘草素;刺蒺藜提取物;刺蒺藜提取物Tribulus Terrestris P.E.;纳米刺蒺藜提取物;异甘草素 Isoliquiritigenin 标准品;异甘草素（标准品）;异甘草素,Isoliquiritigenin,植物提取物,标准品,对照品;异甘草素标准品;(E)-1-(2,4-二羟苯基)-3-(4-羟基苯基)-2-丙烯-1-酮;2',4,4'-三羟基查尔酮;4,2',4'-三羟基查耳酮;分析对照品;异甘草素(异甘草苷元,4,2',4'-三羟基查耳酮,4,2',4'-三羟基查耳酮);异甘草素,Isoliquiritigenin,对照品,标准品,中草药;异甘草素,Isoliquiritigenin,分析标准品
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| 英文名称 |
Isoliquiritigenin
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| 英文别名 |
Isoliquiritigenin;2',4,4'-TRIHYDROXYCHALCONE;(e)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;2’,4,4’-trihydroxy-chalcon;4,4’-trihydroxychalcone(e)-2;4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-1-((e)-2-propen-1-on;gu17;ISOLIQUIRITIGENIN(P);ISOLIQUIRITIGENIN(RG);(E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one, 4,2μ,4μ-;Trihydroxychalcone;(E)-2',4,4'-Trihydroxychalcone;2',4,4'-Trihydroxy-trans-chalcone;2-Propen-1-one,1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)-, (2E)-;Isoliquiritigenin（ISL,GU 17, ILTG）;2',4',4-TRIHYDROXYCHALCONE;4,2',4'-TRIHYDROXYCHALCONE;GU-17;ISL;Isoliquiritigen;Isoliquiritigenin,4,2',4'-Trihydroxychalcone;ISOLIQUIRTIGENIN;Isqliquiritigenin;4,2′,4′-Trihydroxychalcone;[
""
];6'-deoxychalcone;(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;GU 17;C15H12O4;Chalcone, 2',4,4'-trihydroxy-;B9CTI9GB8F;42'4'-trihydroxychalcone;1-(2,4-Dihydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one;(2E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one;2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-h
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| Cas No. |
961-29-5
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| 分子式 |
C15H12O4
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| 分子量 |
256.25
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| 包装储存 |
Powder； -20°C； 3 years; 4°C； 2 years；
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| 生物活性 |
Isoliquiritigenin is an anti-tumor flavonoid from the root of Glycyrrhiza uralensisFisch., which inhibits aldose reductase with an IC50 of 320 nM. Isoliquiritigenin is a potent inhibitor of influenza virus replication with an EC50 of 24.7 μM.
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|---|---|
| 性状 |
Solid
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| IC50 & Target[1][2] |
IC50: 320 nM (Aldose reductase)
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| 体外研究(In Vitro) |
Isoliquiritigenin may prevent diabetic complications through inhibiting rat lens aldose reductase with an IC50 of 320 nM and sorbitol accumulation in human red blood cells with an IC50 of 2.0 μM. Isoliquiritigenin (100 μM) markedly inhibits the hypoxia-induced prolonged TPS and TR90 of cardiomyocytes. Isoliquiritigenin significantly triggers AMPK Thr172 phosphorylation as compared with vehicle group. Isoliquiritigenin treatment also induces extracellular signal-regulated kinase (ERK) signaling pathway in the cardiomyocytes. Isoliquiritigenin treatment significantly decreases the intracellular ROS levels of isolated cardiomyocytes during hypoxia/reoxygenation. Isoliquiritigenin not only downregulates IL-6 expression but also significantly decreases levels of phosphorylated ERK and STAT3 and can inhibit phosphorylation levels of ERK and STAT3 induced by rec
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| 体内研究(In Vivo) |
Isoliquiritigenin shows concentration-dependent inhibition of the tonic contraction of mouse jejunum induced by various types of stimulants such as CCh (1 mM), KCl (60 mM) and BaCl2 (0.3 mM) with IC50 values of 4.96±1.97 mM, 4.03±1.34 mM and 3.70±0.58 mM, respectively. Isoliquiritigenin exhibits significant anti-tumor activity in MM xenograft models and synergistically enhances the anti-myeloma activity of adriamycin.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
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| 运输条件 |
Room temperature or refrigerated transport.
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| 储存方式 |
Powder； -20°C； 3 years; 4°C； 2 years；
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| 结构分类 |
FlavonoidsChalco
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| 来源 |
Plants
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| 溶解度数据 |
体外研究:DMSO : ≥ 100 mg/mL(390.24 mM)Ethanol : 100 mg/mL(390.24 mM;Need ultrasonic)*≥ means soluble, but saturation unknown.
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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。
2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。
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