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Apigenin.

(Synonyms: 芹菜素; 4',5,7-Trihydroxyflavone; Apigenol; C.I. Natural Yellow 1)

目录号: PC58217 纯度: 10mM*1mLinDMSO

Apigenin (4',5,7-Trihydroxyflavone) 是一种竞争性 CYP2C9 抑制剂，Ki 为 2 μM。Apigenin (4',5,7-Trihydroxyflavone) 是一种竞争性 CYP2C9 抑制剂，Ki 为 2 μM。

CAS No. :520-36-5

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中文名称	Apigenin.
中文别名	芹菜素;5,7,4'-三羟基黄酮;芹黄素;芹菜(甙)配基;芹菜甙元;芹菜苷元;芹菜苷配基;芹菜配基;芹菜素 USP标准品;芹菜素(标准品);芹菜素植物提取物,标准品,对照品;芹菜素对照品;芹菜提取物;芹黄素(AS);芹黄素(RG);桑寄生提取物;4',5,7-三羟基黄酮;5,7-二羟基-2-(4-羟基苯基)-4H-苯并吡喃-4-酮;芹黄素,4',5,7-三羟基黄酮,5,7,4'-三羟基黄酮;5,7,4’-三羟基黄酮;甘菊;黄春菊;母菊提取物;芹菜素标准品;洋甘菊提取物;洋芹素;芹菜甙元芹菜素;甘菊,黄春菊;芹菜素，芹黄素
英文名称	Apigenin
英文别名	5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;4',5,7-TRIHYDROXYFLAVONE;4,5,7-TRIHYDROXYFLAVONE;4',5,7-TRIHYROXYFLAVONE;5,7,4'-TRIHYDROXYFLAVONE;5,7-DIHYDROXY-2-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE;7,4',5-TRIHYDROXYFLAVONE;APIGENIN;CHAMOMILE;2-(p-hydroxyphenyl)-5,7-dihydroxychromone;4’,5,7-trihydroxyflavaone;4’,5,7-trihydroxy-flavon;5,7-dihydroxy-2-(4-hydroxyphenyl)-4h-1-benzopyran-4-on;apigenine;c.i.naturalyellow1;5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone;4,5,7-Trihydroxyflavone (apigenin);APIGENIN CRYSTALLINE;APIGENIN FROM PARSLEY;Matricaria chamomilla flower;APIGENIN(AS) PrintBack;APIGENIN(P) (Compendial Traceable);APIGENIN(P) (Compendial Traceable) PrintBack;APIGENIN(RG)(REQUEST QUOTE) PrintBack;apigenol;Celery seed extract;Pelargidenone;Versulin;Versuline;4′,5,7-Trihydroxyflavone;[ "4'", "5", "7-Trihydroxyflavone" ];4';Spigenin;C.I. Natural Yellow 1;Pelargidenon 1449;UCCF 031;5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one;FLAVONE, 4',5,7-TRIHYDROXY-;4H-1-Benzopyran-4-one, 5,7-;4',5,7-Trihydroxyflavone;Apigenol
Cas No.	520-36-5
分子式	C₁₅H₁₀O₅
分子量	270.24
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；
详情描述	Apigenin (4',5,7-Trihydroxyflavone) 是一种竞争性 CYP2C9 抑制剂，Ki 为 2 μM。Apigenin (4',5,7-Trihydroxyflavone) 是一种竞争性 CYP2C9 抑制剂，Ki 为 2 μM。

生物活性	Apigenin (4,5,7-Trihydroxyflavone) is a competitive CYP2C9 inhibitor with a K_i of 2 μM.
性状	Solid
IC50 & Target[1][2]	CYP2

体外研究(In Vitro)

Apigenin (4,5,7-Trihydroxyflavone) inhibits cytochrome P450 2C9 (CYP2C9) with a Ki of 2 μM in the CYP2C9 RECO system (a purified, reconstituted enzyme system containing recombinant human CYP2C9, P450 reductase, cytochrome b5, and liposomes). Apigenin inhibits the cell proliferation. The growth inhibition rate (IR) of 20, 40, and 80 μM of Apigenin is 38%, 71%, and 99% respectively on the 7d. after exposure to Apigenin for 24 or 48 h, the clone formation of SGC-7901 cells is suppressed in a dose- and time-dependent manner. The cloning efficiency in 80 μM is 9.8% and 5% after treatment with Apigenin for 24 and 48 h, while in the control group it is 40.4% and 43.4%.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Apigenin (4,5,7-Trihydroxyflavone), a natural flavonoid, possesses a broad spectrum of biological properties, including antioxidative, anti-inflammatory, anticancer, and neuroprotective effects. Apigenin (125?mg/kg and 250 ?mg/kg) alleviates Adriamycin (ADR) (24?mg/kg)-induced myocardial injury. Apigenin inhibits serum aspartate amino transferase (AST) release. Apigenin reduces serum lactate dehydrogenase (LDH) release. Apigenin reduces serum creatine kinase (CK) contents.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Flavonoids
Flavon

来源

Plants

溶解度数据	体外研究: DMSO : 83.33 mg/mL(308.36 mM;Need ultrasonic) H₂O : < 0.1 mg/mL (insoluble) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Apigenin.

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