Procyanidin B2|29106-49-8|(原花青素 B2; Proanthocyanidin B2)-陌孚医药/Medlife

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Procyanidin B2 (Synonyms: 原花青素 B2; Proanthocyanidin B2)

目录号: PC58290 纯度: ≥99%

CAS No. :29106-49-8

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中文名称	Procyanidin B2
中文别名	原花青素B2;原矢车菊素B2;原花青素B2对照品;大豆异黄酮-卵磷脂复合物;原花青素B2 标准品;原花青素B2(P);原花青素B2 植物提取物,标准品,对照品;4,8″-二-[(+)-表儿茶素];顺式,顺式″-4,8″-二(3,3′,4′,5,7-五羟基黄烷);原花青素 B2
英文名称	Procyanidin B2
英文别名	Procyanidin B2;Proanthocyanidin B2;[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol,2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-;[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol,2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahy...;PROCYANIDIN B2(P);PROCYANIDIN B2(P) PrintBack;(-)epicatechin-(-)-epicatechin;4,8'-BI-[(+)-EPICATECHIN];EPICATECHIN(4B-8)EPICATECHIN;EPICATECHIN(4BETA->8)EPICATECHIN;PROCYANIDIN B1(P);Procyanidin?B2;PROCYANIDINDIMERB2;Procyanidol B2;(−)-Epicatechin (4β-8)-(−)-epicatechin;(2R,2'R,3R,3'R,4R)-2,2'-Bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-[4,8'-bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol;Epicatechin-(4β→8)-epicatechin;(+)-Procyanidin B2;2,3-cis-proanthocyanidin;L88HKE854X;EC-(4b,8)-EC;Procyanidin B-2;Epicathechin-(4beta->8)-epicathechin;[4,8'-Bi-2H-1-benzopyran]-3,3',5,5',7,7'-hexol, 2,2'-bis(3,4-dihydroxyphenyl)-3,3',4,4'-tetrahydro-, (2R,2'R,3R,3'R,4R)-;C30H26O12;Procyanidin-B2;Procyanidin dimer B2;4,8'-Bi((+)-epicatechin));XFZJEEAOWLFHDH-NFJBMHMQSA-N;Procyanid
Cas No.	29106-49-8
分子式	C₃₀H₂₆O₁₂
分子量	578.52
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Procyanidin B2 is a natural flavonoid, with anti-cancer, antioxidant activities.

性状

Solid

体外研究(In Vitro)

Procyanidin B2 shows antiproliferative activity to MCF-7 cells, with an IC50 of 19.21 μM. However, Procyanidin B2 exhibits no effect on DNA-ladder formation. Procyanidin B2 (0.1, 1, 2 μM) inhibits the activation of pyrin domain containing 3 (NLRP3) inflammasome in human umbilical vein ECs (HUVECs), and the inhibition is via suppression of AP-1 activity, and such effect can be abolished by overexpression of c-Jun. Procyanidin B2 (2 μM for 12 h) also reduces ROS in HUVECs.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Procyanidin B2 (40, 20, and 10 mg/kg, p.o.) protects against cerebral ischemia-induced infarct volume and brain edema in rats. Procyanidin B2 (40 mg/kg, p.o) also improves functional outcomes, regulates blood-brain barrier (BBB) permeability after cerebral ischemia. Moreover, Procyanidin B2 attenuates cerebral ischemia-induced tight junction degradation, mitochondrial depolarization and intracellular oxidative stress. Procyanidin B2 (40 mg/kg, p.o) increases Nrf2 activation and HO-1, GSTα, and NQO1 protein expression in normal brains in vivo.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Flavonoids
Biflav

来源

Plants
other fami

溶解度数据	体外研究: H₂O : 66.67 mg/mL(115.24 mM;Need ultrasonic) DMSO : ≥ 50 mg/mL(86.43 mM) *≥ means soluble, but saturation unknown.

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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