Cephaeline dihydrochloride|5853-29-2|((-)-Cephaeline dihydrochloride; NSC 32944)-陌孚医药/Medlife

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Cephaeline dihydrochloride (Synonyms: (-)-Cephaeline dihydrochloride; NSC 32944)

目录号: PC58687 纯度: ≥99%

CAS No. :5853-29-2

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中文名称	Cephaeline dihydrochloride
中文别名	盐酸吐根酚碱;吐根酚碱盐酸盐 EP标准品;盐酸吐根酚碱标准品
英文名称	Cephaeline dihydrochloride
英文别名	cephaeline hydrochloride;(-)-CEPHAELINE, DIHYDROCHLORIDE;NSC 32944;10,11,7'-trimethoxy-emet-1'-ene-9,6'-diol;10,11,7'-Trimethoxy-emetan-6'-ol,Dihydrochlorid;10,11,7'-trimethoxy-emetan-6'-ol,dihydrochloride;10,11,7'-Trimethoxy-emetan-6'-ol,Hydrochlorid;Alangicine;cephaeline dihydrochloride;(1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol hydrochloride;NSC32944
Cas No.	5853-29-2
分子式	C₂₈H₃₉ClN₂O₄
分子量	503.07
包装储存	4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；

生物活性	Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC₅₀ of 121 μM.
性状	Solid
IC50 & Target[1][2]	IC50: 121 μM (CYP2D6) Ki: 54 μM (CYP2D6)
体外研究(In Vitro)	CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC50s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (Ki) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield Kis of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Sealed and stored away from moisture and light；*In solvent : -80°C, 6 months; -20°C, 1 month (Sealed and stored away from moisture and light)；
结构分类	Alkaloids Isoquin
来源	Plants other fami

溶解度数据	体外研究: DMSO : 250 mg/mL(463.37 mM;Need ultrasonic) H₂O : 125 mg/mL(231.68 mM;Need ultrasonic) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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