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Ginkgetin

(Synonyms: 银杏双黄酮)

目录号: PC58323 纯度: ≥99%

Ginkgetin 是一种从银杏叶中分离得到的双黄酮。Ginkgetin 具有抗肿瘤，抗炎，神经保护，抗真菌的作用。Ginkgetin 也是一种有效的 Wnt 信号抑制剂，IC50 值为 5.92 μM。Ginkgetin 是一种从银杏叶中分离得到的双黄酮。Ginkgetin 具有抗肿瘤，抗炎，神经保护，抗真菌的作用。Ginkgetin 也是一种有效的 Wnt 信号抑制剂，IC50 值为 5.92 μM。

CAS No. :481-46-9

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中文名称	Ginkgetin
中文别名	银杏素;银杏黄酮甙;白果双黄酮,银杏双黄酮,银杏黄素;白果双黄酮;银杏双黄酮;白果双黄酮（银杏素）;银杏黄酮;白果双黄酮,银杏双黄酮;银杏黄素
英文名称	Ginkgetin
英文别名	GINKGETIN;4',5,5'',7-Tetrahydroxy-4''',7''-dimethoxy-8,3'''-biflavone;5,7-Dihydroxy-8-[2-methoxy-5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)phenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;5,7-Dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;GINKGETIN(RG)(PLEASE CALL);4H-1-Benzopyran-4-one,5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl;5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxochromen-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)chromen-4-one;7,4'-di-O-methylamentoflavone;Amentoflavone 7,4'-dimethyl ether;[ "" ];7,4'-Dimethylamentoflavone;AIFCFBUSLAEIBR-UHFFFAOYSA-N;5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-chromen-2-yl)-2-methoxy-phenyl]-2-(4-hydroxyphenyl)chromen-4-one;4H-1-Benzopyran-4-one, 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-hydroxyphenyl)-;4H-1-Benzopyran-4-one, 5,7-dihyd
Cas No.	481-46-9
分子式	C₃₂H₂₂O₁₀
分子量	566.51
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Ginkgetin, a biflavone, is isolated from Ginkgo biloba leaves. Ginkgetin exhibit anti-tumor, anti-inflammatory, neuroprotective, anti-fungal activities. Ginkgetin is also a potent inhibitor of Wnt signaling, with an IC₅₀ of 5.92 μΜ.
性状	Solid
体外研究(In Vitro)	Ginkgetin (2.5-20 μM; 48 h) inhibits the growth of Daoy and D283 cell lines, and induces G2/M cell cycle arrest in Daoy cells. Ginkgetin (20-40 μM; 24 h) significantly activates the apoptosis of osteosarcoma cells in a concentration-dependent manner. Ginkgetin (10-20 μM; 3-24 h) down-regulated the expression of Wnt target genes without affecting the expression of β-catenin in medulloblastoma cells. Ginkgetin (1-10 μM; 24 or 48 h) significantly inhibits the VEGF-induced endothelial cell proliferation, migration, and wound recovery in a concentration-dependent manner. Ginkgetin (5-10 μM; 48 h) induces autophagy responsible for cell death in A549.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Ginkgetin (25-100 mg/kg; i.p. 2 hours after the onset of ischemia) exerts anti-inflammatory effects on cerebral ischemia/reperfusion-induced injury in a rat model via the TLR4/NF-κB signaling pathway. Ginkgetin (30 mg/kg; intragastrically once per day for 42 d) suppresses tumor growth in A549 cells bearing nude mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only. <
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Flavonoids Biflav
来源	Plants

溶解度数据	体外研究: DMSO : ≥ 20.83 mg/mL(36.77 mM) *≥ means soluble, but saturation unknown. 配制储存液

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Ginkgetin

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