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Capsaicin

(Synonyms: 辣椒素; (E)-Capsaicin)

目录号: PC58202 纯度: 10mM*1mL in DMSO

Capsaicin ((E)-Capsaicin) 是辣椒中的活性成分，是一种 TRPV1 激动剂。Capsaicin 具有减轻疼痛、抗氧化、抗炎、神经保护和抗癌作用。Capsaicinoid 是辣椒素和二氢辣椒素的混合物，是一种辣椒素受体 (TRPV1) 激动剂。

CAS No. :404-86-4

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中文名称	Capsaicin
中文别名	吉西他滨;辣椒碱;8-甲基-N-香草基-L-壬烯胺;(E)-N-(4-羟基-3-甲氧基苄基)-8-甲基-6-壬烯酰胺;天然辣椒碱;天然辣椒素;辣椒碱（天然）;(E)-辣椒素;WAKO039-18981辣椒素标准品;反式辣椒素;辣椒碱 USP标准品;辣椒碱标准品;辣椒碱辣椒提取物;辣椒碱植物提取物,标准品,对照品;辣椒碱,辣椒素(天然提取);辣椒碱,辣椒素（天然提取标准品）;辣椒精;辣椒素;辣椒素 EP标准品;辣椒素(P);莱苞迪苷A;8-甲基-N-[(4-羟基-3-甲氧基苯基)-甲基]-(反)-6-壬烯基酰胺;8-甲基-N-香草基-反-6-壬烯酰胺;辣椒素标准品分析对照品;辣椒素(天然);辣椒碱减肥瘦身;吉西他滨,合成辣椒碱;辣椒素合成的;辣椒碱，辣椒素;辣椒提取物
英文名称	Capsaicin
英文别名	capsaicin;CAPSAICINE;CAPSAICIN, NATURAL;(E)-8-METHYL-NON-6-ENOIC ACID 4-HYDROXY-3-METHOXY-BENZYLAMIDE;(E)-CAPSAICIN;(E)-N-([4-HYDROXY-3-METHOXYPHENYL]METHYL)8-METHYL-6-NONEAMIDE;(E)-N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE;FEMA 2787;FEMA 3404;N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6E-NONENAMIDE;N-[(4-HYDROXY-3-METHOXYPHENYL)METHYL]-8-METHYL-6-NONENAMIDE;TRANS-8-METHYL-N-VANILLYL-6-NONENAMIDE;(e)-6-nonenamid;capsaicin(fromoleoresinofcapsicum)plusrelatedcapsaicinoids;nci-c56564;trans-n-((4-hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide;Capsaicin (Natural);(E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide;Capsaicin (technical grade);CAPSAICIN(METHYL-N-VANILLYL-6-NONENEAMIDE)(P) PrintBack;Capsaicin,Natural Solution;trans-Capsaicin;(E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide;8-Methyl-N-vanillyl-6-nonenamide;8-methyl-N-vanillyl-trans-6-nonenamide;8-Methyl-N-vanillyl-trans-6-nonenamide,Capsaicin;Axsain;Qutenza;trans-8-methyl-n-vanill;Transacin;Zostrix;(E)-8-Methyl-N-vanillyl-6-nonenamide;NONIVAMIDE;N-Vanillylnonanamide;Pseudocapsaicin;Pelargonic acid vanillylamide;N-Vanillylnonamide;N-Vanillylpelargonamide;N-(4-Hydroxy-3-methoxybenzyl)nonanamide;Nonanoic acid vanillylamide;N-Nonanoyl vanillylamide;Vanillyl-N-nonylamide;Pelargonyl vanillylamide;Vanillyl pelargonic amide;Nonylic acid vanillylamide;Vanillyl n-nonoylamide;Hydroxymethoxybenzyl pelargonamide;Nonanamide, N-vanillyl-;Nonylvanylamide;Nonanoyl vanillylamide;Nonanamide, N-[(4-hydroxy-3-methoxyphenyl)methyl]-;Chili pepper Extract;Chili pepper Extract
Cas No.	404-86-4
分子式	C₁₇H₂₇NO₃
分子量	293.40
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性

Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects.

性状

Solid

IC50 & Target[1][2]

EC50: 290 nM (hTRPV1, in HEK293 cell)

体外研究(In Vitro)

Capsaicin (50-300 μM; 24-72 hours) shows an augmented decrease in cell growth in a dose- and time-dependent manner. The observed IC50 value is around 150 μM.
Capsaicin (50-300 μM; 24-72 hours) shows increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels, and decreases anti-apoptotic Bcl-2 protein and increases pro-apoptotic Bad/Bax expression.
Capsaicin increases the nuclear condensation, nuclear DNA fragmentation and sub-G1 DNA content.
Capsaicin suppresses the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Capsaicin suppresses the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Phenols
Monopheno

来源

Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(327.43 mM;Need ultrasonic) Ethanol : 100 mg/mL(327.43 mM;Need ultrasonic) 配制储存液

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Capsaicin

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