您当前的位置：

Etoposide.

(Synonyms: 依托泊苷; VP-16; VP-16-213)

目录号: PC57575 纯度: ≥99%

Etoposide (VP-16; VP-16-213) 是一种常用的抗肿瘤化疗剂。Etoposide 抑制拓扑异构酶 II (topoisomerase-II)，从而抑制 DNA 复制。Etoposide 诱导细胞周期停滞，凋亡 (apoptosis) 和自噬 (autophagy)。

CAS No. :33419-42-0

商品编号	规格	价格	会员价
PC57575-100mg	100mg	¥636.00	请登录
PC57575-200mg	200mg	¥1086.00	请登录
PC57575-1mL	1mL	¥700.00	请登录

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

*注意事项:下单时请联系销售核实产品价格及货期，避免后续产生不便，感谢支持!

加入购物车在线咨询收藏产品大包装询价

中文名称	Etoposide.
中文别名	依托泊苷;足叶乙苷;表鬼臼毒吡喃葡萄糖苷;依托泊甙;足叶乙甙;鬼臼亚乙基苷;4'-去甲基表鬼臼毒素-beta-D-乙叉吡喃葡萄糖甙;依托泊甘;2,3,5,6-四氟-4-羟基苯甲醛;Etoposide 依托泊甘;依托泊甙,0;依托泊甙标准品(JP);依托泊甘(约含的乙醇);依托泊苷 EP标准品;依托泊苷 USP标准品;依托泊苷标准品;依托泊苷分离度用混合物 USP标准品;依托泊苷系统适应性 EP标准品;4'-去甲表鬼臼9 -（4,6-O-亚乙基-β-e-吡喃葡萄糖苷）VP-16-213;9-[4,6-O-（R）-亚乙基-β-D-吡哺葡萄糖苷]-4'-去甲基表鬼臼毒素;鬼臼乙叉苷;依托泊苷、鬼臼亚乙基苷;依托泊苷对照品;4'-去甲基表鬼臼毒素 9-(4,6-O-亚乙基-β-D-吡喃葡萄糖苷)
英文名称	Etoposide
英文别名	Etoposide;TENIPOSIDE;4'-demethylepipodophyllotoxin-(4,6-o-(r)-ethylidene-beta-d-glucopyranoside);4-demethylepipodophyllotoxin-beta-d-ethylideneglucoside;ETOPOSIDE(RG);4‘-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside);4'-Demethylepipodophyllotoxin 9-(4,6-O-Ethylidene-β-D-glucopyranoside);Demethylepipodophyllotoxin-beta-D-ethylideneglucoside;VP16;VP-16;VP16213;VP-16-213;4′-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-β-D-glucopyranoside)
Cas No.	33419-42-0
分子式	C₂₉H₃₂O₁₃
分子量	588.56
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
详情描述	Etoposide (VP-16; VP-16-213) 是一种常用的抗肿瘤化疗剂。Etoposide 抑制拓扑异构酶 II (topoisomerase-II)，从而抑制 DNA 复制。Etoposide 诱导细胞周期停滞，凋亡 (apoptosis) 和自噬 (autophagy)。

生物活性	Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.
性状	Solid
IC50 & Target[1][2]	Topoisomerase II

体外研究(In Vitro)

Etoposide is capable of causing cytotoxicity on pancreatic β-cells by inducing apoptosis through the JNK/ERK-mediated GSK-3 downstream-triggered mitochondria-dependent signaling pathway in RIN-m5F cells.
Etoposide and Anti-Human VEGF significantly abolish P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells.
Etoposide phosphate (0-1μM; 72 hours) inhibits HCT116 FBXW, FBXW and p53 as a dose-dependent manner, exhibits IC50s of 0.945 μM; 0.375 μM; and 1.437 μM, respectively.
Etoposide (25 μM; 6 hours) delays p53 recover in FBXW7-deficient cells. In addition, FBXW7 expression is disappeared in FBXW7 cells.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Etoposide (50 μM) and Anti-Human VEGF-treated hypoxic cells injected intravenously into immunodeficient mice reveals a reduced capacity to induce lung colonies, which also appear with a longer latency period. Etoposide (10 mg/kg/day, i.v.) with NSC 109724 and NSC 241240, reduces the tumor volume in the hepatoblastoma cell injected NMRI nude mice.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

ClinicalTrial

结构分类

Phenylpropanoids

来源

Plants

溶解度数据	体外研究: DMSO : ≥ 39 mg/mL(66.26 mM) *≥ means soluble, but saturation unknown. 配制储存液

搜索质检报告(COA)

产品使用指南

Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Etoposide.

相关产品

The molarity calculator equation

The dilution calculator equation