Macelignan|107534-93-0|(安五脂素; (+)-Anwulignan; Anwuligan)-陌孚医药/Medlife

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Macelignan (Synonyms: 安五脂素; (+)-Anwulignan; Anwuligan)

目录号: PC57758 纯度: ≥99%

CAS No. :107534-93-0

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中文名称	Macelignan
中文别名	安五脂素;安五酯素;安五脂素植物提取物,标准品,对照品;安五脂素对照品;安五脂素 (安五酯素);安五脂素, 来源于五味子;ANWULIGAN 安五酯素
英文名称	Macelignan
英文别名	(+)-Anwulignan;Anwuligan;ANWULIGNAN;4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxyphenol;Macelignan;Phenol,4-[(2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-diMethylbutyl]-2-Methoxy-;Calophyn;austrobailignan 6;HMS2219A18;UNII-8PP3614Z43;4-[(2S,3R)-4-(1,3-Benzodioxol-5-yl)-2,3-dimethylbutyl]-2-methoxy-phenol;MLS000728494;8PP3614Z43;SMR000445701;Phenol, 4-((2S,3R)-4-(1,3-benzodioxol-5-yl)-2,3-dimethylbutyl)-2-methoxy-;(+)-Anwulignan;Anwuligan;Macelignan, >=98% (HPLC);BDBM90735;cid_10404245;(8R,8'S)-7-(3,4-methylenedioxyphenyl)-7';(8R,8'S)-7-(3,4-methylenedioxyphenyl)-7'-(4-hydroxy-3-methoxyphenyl)-8,8'-dimethylbutane;HMS22
Cas No.	107534-93-0
分子式	C₂₀H₂₄O₄
分子量	328.40
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Macelignan ((+)-Anwulignan; Anwuligan) is an orally active lignan isolated from Myristica fragrans. Macelignan possesses many pharmacological activities, including anti-inflammatory, anti-cancer, anti-diabetes, and neuroprotective activities.
性状	Solid
IC50 & Target[1][2]	COX-2

体外研究(In Vitro)

Macelignan (1-50 μM; 72 hours) does not reduce cell viability alone, however, UVB treatment, even at the lowest dose of 30 mJ/cm, reduces HaCaT cell viability in a dose-dependent mannner,it reduces approximately 80% of control values at 100 μM in hacat cells.
Macelignan (0.1-1 μM; 24 hours) decreases COX-2 expression in a concentration-dependent manner,and at the highest concentration of macelignan (1 μM) , COX-2 expression is inhibited by almost 50% in hacat cells.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
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体内研究(In Vivo)

Macelignan (oral administration; 15 mg/kg; every day for three weeks) exhibits in vivo anti-diabetic effects. The baseline (day 0) fasting blood glucose levels does not differ between groups; at the end of the experiment, the values of the Macelignan-treated group are significantly lower compared to the diabetic control group in C57BL/KsJ-db/db mice.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

结构分类

Phenylpropanoids

来源

Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(304.51 mM;Need ultrasonic) 配制储存液

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