We designed and synthesised an anionic small-molecular photosensitizer (aPSM-Cy3.5) for incorporation into electrostatic antibody targeted (ELART) vesicles, consisting of a protamine-coupled antibody as targeting unit, free protamine and aPSM-Cy3.5. These nanocarriers specifically internalize into different solid tumour cell lines. Upon illumination, the aPSM component initiates the production of reactive oxygen species (ROS). Tumour cells from lung, colorectal and pancreatic cancer with internalized aPSM show decreased growth in colony forming assay. This supports the development of systemically applicable anionic ROS inducers capable of specifically targeting tumour cells.
Photodynamic ROS inducers delivered via electrostatic antibody targeted (ELART) nanocarriers incorporate into tumour cells and inhibit colony growth.
发布日期：2026/10/27 14:04:43
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