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cAMPS-Rp, triethylammonium salt

目录号: PC11828 纯度: ≥98%

细胞渗透性cAMP类似物，cAMP诱导的PKA激活的竞争性拮抗剂,Rp-cAMPS triethylammonium salt 是 cAMP 的类似物，可作为 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化 (Ki 分别为 6.05 µM 和 9.75 µM) 的有效，竞争性和细胞渗透性拮抗剂。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。

CAS No. :151837-09-1

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中文名称	cAMPS-Rp, triethylammonium salt
中文别名	9-咔唑乙醇;腺苷-3'',5''-环状硫代磷酸三乙基铵盐,Rp-异构体;(R)-腺苷环3',5'-(硫代磷酸氢酯)三乙胺盐
英文名称	cAMPS-Rp, triethylammonium salt
英文别名	cAMPS-Rp, triethylammonium salt;ADENOSINE- 3', 5'- CYCLIC MONOPHOSPHOROTHIOATE, RP- ISOMER ( RP-CAMPS ), ECONOMY GRADE;Rp-Cyclic AMPS;Rp-Cyclic AMPS (triethylammonium salt);RP-CAMPS TEA;CAMPS TEA, RP-ISOMER;OXIPZMKSNMRTIV-RNSTXJOVSA-N;RP-CAMPS TRIETHYL AMMONIUM SALT;rp-camps triethylammonium salt hydrate;ADENOSINE 3',5'-CYCLIC PHOSPHOROTHIOATE-RP, TRIETHYLAMMONIUM SALT;Rp-Adenosine 3′,5′-cyclic monophosphorothioate triethylammonium salt;Rp-Cyclic 3′,5′-hydrogen phosphorothioate adenosine triethylammonium salt;Rp-cAMPS triethylammonium salt
Cas No.	151837-09-1
分子式	C₁₀H₁₁N₅O₅PS-^.C₆H₁₆N+
分子量	446.46
包装储存	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
详情描述	细胞渗透性cAMP类似物，cAMP诱导的PKA激活的竞争性拮抗剂,Rp-cAMPS triethylammonium salt 是 cAMP 的类似物，可作为 cAMP 诱导的依赖 cAMP 的 PKA I 和 PKA II 活化 (Ki 分别为 6.05 µM 和 9.75 µM) 的有效，竞争性和细胞渗透性拮抗剂。Rp-cAMPS triethylammonium salt 耐磷酸二酯酶水解。

生物活性	Rp-cAMPS triethylammonium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (K_is of 12.5 μM and 4.5 μM, respectively) antagonist. Rp-cAMPS triethylammonium salt is resistant to hydrolysis by phosphodiesterases.
性状	Solid
IC50 & Target[1][2]	Ki: 6.05 μM (PKA I) and 9.75 μM (PKA II)
体外研究(In Vitro)	A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons. Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature or refrigerated transportation.
储存方式	-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
参考文献	[1]. R J de Wit, et al. Inhibitory action of certain cyclophosphate derivatives of cAMP on cAMP-dependent protein kinases. Eur J Biochem. 1984 Jul 16;142(2):255-60. [Information] [2]. Rothermel JD, et al. A mechanistic and kinetic analysis of the interactions of the diastereoisomers of adenosine 3,5-(cyclic)phosphorothioate with purified cyclic AMP-dependent protein kinase. Biochem J. 1988 May 1;251(3):757-62. [Information] [3]. Fu Y, et al. PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior. Mol Pain. 2008 Jul 16;4:26. [Information] [4]. Kuriyama S, et al. Isoproterenol inhibits rod outer segment phagocytosis by both cAMP-dependent and independent pathways. Invest Ophthalmol Vis Sci. 1995 Mar;36(3):730-6. [Information] [5]. Dostmann WR, et al. Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3,5-cyclic phosphorothioates. J Biol Chem. 1990 Jun 25;265(18):10484-91. [Information] [6]. Van Haastert PJ, et al. Competitive cAMP antagonists for cAMP-receptor proteins. J Biol Chem. 1984 Aug 25;259(16):10020-4. [Information]

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cAMPS-Rp, triethylammonium salt

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