Gly-Arg-Gly-Asp-Ser|96426-21-0|-陌孚医药/Medlife

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Gly-Arg-Gly-Asp-Ser

目录号: PL12625 纯度: ≥99%

CAS No. :96426-21-0

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中文名称	Gly-Arg-Gly-Asp-Ser
中文别名	甘氨酰精氨酰甘氨酰天门冬氨酰丝氨酸
英文名称	Gly-Arg-Gly-Asp-Ser
英文别名	L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl-;GLY-ARG-GLY-ASP-SER;GRGDS;H-Gly-Arg-Gly-Asp-Ser-OH;2ACOH 2H2O;Gly-Arg-Gly-Asp-Ser-OH;glycyl-arginyl-glycyl-aspartyl-serine;GRGDS 1;GRGDS,FIBRONECTIN ATTACHMENT PEPTIDE;L-Serine,glycyl-L-arginylglycyl-L-a-aspartyl;L-Serine, N-[N-[N-(N2-glycyl-L-arginyl)glycyl]-L-α-aspartyl]- (ZCI);L;Glycyl-L-arginylglycyl-L-α-aspartyl-L-serine (ACI);103: PN: WO2012045822 PAGE: 9 unclaimed sequence;10: PN: WO2011036326 SEQID: 14 unclaimed protein;11: PN: JP2003089648 SEQID: 12 unclaimed;11: PN: US20050118158 SEQID: 11 unclaimed sequence;11: PN: WO2010033220 SEQID: 76 unclaimed protein;12: PN: KR20090132815 PAGE: 3 claimed sequence;12: PN: KR20090132911 SEQID: 107 claimed protein;12: PN: US20130052712 SEQID: 13 claimed protein;13: PN: JP2004000070 SEQID: 15 unclaimed protein;13: PN: KR20160113372 SEQID: 13 claimed sequence;13: PN: KR20160129982 SEQID: 13 claimed sequence;13: PN: WO03020279 PAGE: 61 unclaimed sequence;13: PN: WO2011025158 SEQID: 13 claimed sequence;154: PN: WO2021030905 SEQID: 167 claimed protein;15: PN: JP2003210166 SEQID: 15 unclaimed protein;15: PN: JP2004049921 SEQID: 15 unclaimed protein;15: PN: KR20120114072 SEQID: 13 unclaimed protein;15: PN: WO2008032712 SEQID: 16 unclaimed sequence;16: PN: US20140004158 SEQID: 17 claimed sequence;16: PN: WO2006075784 SEQID: 16 claimed sequence;16: PN: WO2014022515 SEQID: 16 unclaimed protein;17: PN: WO03037247 SEQID: 15 unclaimed sequence;18: PN: WO2021024265 SEQID: 23 claimed protein;1: PN: JP2004000471 SEQID: 15 unclaimed protein;1: PN: JP2013135740 PAGE: 2 claimed sequence;1: PN: US20100168025 SEQID: 1 unclaimed protein;1: PN: WO0063247 SEQID: 26 unclaimed sequence;1: PN: WO0200270 SEQID: 5 claimed protein;1: PN: WO2006115295 SEQID: 5 unclaimed sequence;1: PN: WO2010104208 SEQID: 1 claimed sequence;1: PN: WO2013002311 SEQID: 1 claimed protein;1: PN: WO2013181713 SEQID: 1 claimed protein;1: PN: WO2015117158 SEQID: 3 claimed sequence;20: PN: GB2411230 PAGE: 10 unclaimed sequence;20: PN: KR20140027031 SEQID: 21 claimed protein;213: PN: WO2014145050 SEQID: 237 claimed protein;21: PN: US20040242483 SEQID: 7 unclaimed sequence;21: PN: WO2010033240 SEQID: 76 unclaimed sequence;22: PN: US20050036980 SEQID: 22 claimed sequence;22: PN: WO02074968 SEQID: 22 unclaimed sequence;23: PN: WO2012082950 PAGE: 70 claimed sequence;24: PN: WO2008050907 SEQID: 24 claimed sequence;25: PN: JP2009072081 SEQID: 63 unclaimed protein;27: PN: FR2860236 PAGE: 6 claimed protein;2: PN: EP2988130 SEQID: 2 claimed protein;2: PN: JP2002369878 SEQID: 12 unclaimed sequence;2: PN: JP2006045206 PAGE: 20 claimed sequence;2: PN: JP2006045207 PAGE: 21 claimed sequence;Gly-Arg-Gly-Asp-Ser
Cas No.	96426-21-0
分子式	C₁₇H₃₀N₈O₉
分子量	490.47
包装储存	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year

产品详情	Gly-Arg-Gly-Asp-Ser 是一种五肽，构成了糖蛋白，骨桥蛋白与细胞的结合域。
生物活性	Gly-Arg-Gly-Asp-Ser is a pentapeptide that forms the cell-binding domain of a glycoprotein, osteopontin. Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3 and αvβ5 with estimated IC 50 of ～5 and ～6.5 μM
性状	Solid
IC50 & Target[1][2]	IC50: 5 μM (αvβ3), 6.5 μM (αvβ5)
体外研究(In Vitro)	Gly-Arg-Gly-Asp-Ser binds to integrin receptors αvβ3, with IC50 of 5 μM. Gly-Arg-Gly-Asp-Ser-immobilized TiO2 nanotubes enhance osteoblast-like cell (MG-63) adhesion, and significantly increased cell spreading and proliferation. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Sealed storage, away from moisturePowder -80°C 2 years；-20°C 1 year
SequenceShortening	GRGDS
Sequence	Gly-Arg-Gly-Asp-Ser
参考文献	[1]. Bernhagen D, et al. High-Affinity RGD-Knottin Peptide as a New Tool for Rapid Evaluation of the Binding Strength of Unlabeled RGD-Peptides to αvβ3, αvβ5, and α5β1 Integrin Receptors. Anal Chem. 2017 Jun 6;89(11):5991-5997. [2]. Kim GH, et al. Evaluation of Osteoblast-Like Cell Viability and Differentiation on the Gly-Arg-Gly-Asp-Ser Peptide Immobilized Titanium Dioxide Nanotube via Chemical Grafting. J Nanosci Nanotechnol. 2016 Feb;16(2):1396-9.

溶解度数据	In Vitro: DMSO : 50 mg/mL (101.94 mM; Need ultrasonic)H₂O : 33.33 mg/mL (67.96 mM; Need ultrasonic)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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