Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC 50 s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ~300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC 50 , 14 μM).
Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca stores mediated by the ryanodine receptor. Chlorantraniliprole is ~300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)
Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD 50 of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years;4°C 2 years
参考文献
[1]. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.