Chlorantraniliprole|500008-45-7|-陌孚医药/Medlife

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Chlorantraniliprole

目录号: PL08418 纯度: ≥98%

CAS No. :500008-45-7

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中文名称	Chlorantraniliprole
中文别名	氯虫苯甲酰胺;康宽;氯虫酰胺;3-溴-N-[4-氯-2-甲基-6-[(甲氨基甲酰基)苯]-1-(3-氯吡啶-2-基)-1H-吡唑-5-甲酰胺;3-溴-4′-氯-1-(3-氯-2-吡啶)-2′-甲基-6′-(甲氨基甲酰基)吡唑-5--甲酰苯胺;3-溴-N-[4-氯-2-甲基-6-[(甲氨基)羰基]苯基]-1-(3-氯-2-吡啶基)-1H-吡唑-5-甲酰胺;氯虫苯甲酰胺溶液, 100PPM;3-溴-N-[4-氯-2-甲基-6-[(甲氨基甲酰基)苯]-1-(3-氯吡啶-2-基)-1-氢-吡啶-5-甲酰胺氯虫酰胺(康宽);WAKO038-21261氯虫苯甲酰胺标准品;氯虫苯甲酰胺标准品;氯虫苯甲酰胺原药
英文名称	Chlorantraniliprole
英文别名	Chlorantraniliprole;3-Bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide;3-Bromo-4-chloro-1-(3-chloro-2-pyridyl)-2-methyl-6-(methylcarbamoyl)pyrazole-5-carboxanilide;Chlorantraniliprole [iso];Rynaxpyr;Chlorantranilipol;5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide;CHLOANTRANILIPROLE;Chlorantraniliprole Standard;CHLORANTRANILIPROLE,IN-HOUSE STANDARD;3-bromo-4’-chloro-1-(3-chloro-2-pyridyl)-2’-methyl-6’-(methylcarbamoyl)pyrazole-5-carboxanilide;3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide;3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-car
Cas No.	500008-45-7
分子式	C₁₈H₁₄N₅O₂Cl₂Br
分子量	483.15
包装储存	Powder -20°C 3 years；4°C 2 years

产品详情	Chlorantraniliprole 是一种杀虫剂，能够有效地、选择性地激活兰诺定受体 (ryanodine receptor)，对黑腹果蝇和烟芽夜蛾的 ryanodine 受体 EC₅₀ 值分别为 40 nM 和 50 nM，对其选择性是对小鼠骨骼肌 2C12 细胞 ryanodine 受体 (EC₅₀，14 μM) 的 300 多倍。
生物活性	Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor, with EC 50 s of 40 nM and 50 nM for Drosophila melanogaster and H. virescens ryanodine receptor, and ～300-fold more potent than that in the mouse myoblast cell line, C2C12 (EC 50 , 14 μM).
性状	Solid
IC50 & Target[1][2]	EC50: 40 nM (Drosophila melanogaster Ryanodine receptor), 50 nM (H. virescens Ryanodine receptor), 14 μM (Ryanodine receptor, in C2C12 cells)
体外研究(In Vitro)	Chlorantraniliprole is an insecticide that potently and selectively activates insect ryanodine receptor. Chlorantraniliprole actions by release of intracellular Ca stores mediated by the ryanodine receptor. Chlorantraniliprole is ～300-fold less potent against ryanodine receptor (RyRs) in the mouse myoblast cell line, C2C12 (EC50, 14 μM), than in insect RyRs from Drosophila melanogaster and H. virescens (EC50, 40 nM, 50 nM), and shows little selectivity at the rat cell line RyR2 (EC50, >100 μM). has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究(In Vivo)	Chlorantraniliprole has low acute mammalian toxicity with an acute oral LD 50 of >5000 mg/kg in rats, and little to no toxicity in 90-day studies, at dosing as high as 1500 mg/kg/day. has not independently confirmed the accuracy of these methods. They are for reference only.
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Powder -20°C 3 years；4°C 2 years
参考文献	[1]. George P.Lahm, et al. Rynaxypyr: A new insecticidal anthranilic diamide that acts as a potent and selective ryanodine receptor activator. Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15;17(22):6274-6279.

溶解度数据	In Vitro: DMSO : ≥ 62.5 mg/mL (129.36 mM)配制储备液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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