Lupiwighteone|104691-86-3|(黄羽扇豆魏特酮; 8-prenylgenistein)-陌孚医药/Medlife

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Lupiwighteone (Synonyms: 黄羽扇豆魏特酮; 8-prenylgenistein)

目录号: PC58908 纯度: ≥98%

CAS No. :104691-86-3

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中文名称	Lupiwighteone
中文别名	黄羽扇豆魏特酮;5,7-二羟基-3-(4-羟基苯基)-8-(3-甲基-2-丁烯)-4H-1-苯并吡喃-4-酮
英文名称	Lupiwighteone
英文别名	Lupiwighteone;4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-buten-1-yl)-;5,7,4'-Trihydroxy-8-(3,3-dimethylallyl)isoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;8-Prenylgenistein;[ "" ];8-Isopentenylgenistein;4',5,7-Trihydroxy-8-prenylisoflavone;4',5,7-Trihydroxy-8-isopentenylisoflavone;3-(4-Hydroxyphenyl)-5,7-dihydroxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;5,7,4'-Trihydroxy-8-prenylisoflavone;5,7-dihydroxy-3-(4-hydroxyphenyl)-8-(3-methylbut-2-enyl)chromen-4-one;MEGxp0_000421;BCP06418;LMPK12050196;4H-1-Benzopyran-4-one,5,7-dihydroxy-3- (4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-;C3012;5,7-Dihydroxy-3-(4-hydroxyphenyl)-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one, 9CI;5,7-Dihydroxy-3-(4-hydroxyphenyl)-8
Cas No.	104691-86-3
分子式	C₂₀H₁₈O₅
分子量	338.35
包装储存	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

生物活性	Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway.
性状	Solid
IC50 & Target[1][2]	apoptosis
体外研究(In Vitro)	Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC50s of 23.7 μM and 21 μM, respectively. Lupiwighteone (20-60 μM; 48 hours) induces (cell cycle arrest in DU-145 cells. Lupiwighteone (20-60 μM; 48 hours) induces cells apoptosis. Lupiwighteone (20-60 μM; 48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU-145 cells. Lupiwighteone (20-60 μM; 48 hours) induces a dose-dependent increase in ROS production. Lupiwighteone up-regulates of cytochrome c and caspase-3, and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression, suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells. Medlife has not independently co
运输条件	Room temperature or refrigerated transport.
储存方式	4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；
结构分类	Flavonoids Isofla
来源	Plants other fami

溶解度数据	体外研究: DMSO : 100 mg/mL(295.55 mM;Need ultrasonic) 配制储存液

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