Andrographolide|5508-58-7|(穿心莲内酯; Andrographis)-陌孚医药/Medlife

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Andrographolide (Synonyms: 穿心莲内酯; Andrographis)

目录号: PC64067 纯度: ≥99%

CAS No. :5508-58-7

商品编号	规格	价格	会员价	是否有货	数量
PC64067-1mg	1mg	询价	询价
PC64067-500mg	500mg	¥2555.00	请登录

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中文名称	Andrographolide
中文别名	穿心莲内酯;心莲乙素;雄茸内酯;穿心莲;穿心连内酯;穿心连内脂;穿心莲内酯, 来源于穿心莲;白柳皮提取物;吡罗西康;穿琥宁;穿心莲内脂;穿心莲内酯 USP标准品;穿心莲内酯标准品;穿心莲内酯(P);穿心莲内酯(SH);穿心莲内酯（标准品）;穿心莲内酯对照品;穿心莲内酯对照品标准品;穿心莲提取物;头孢替坦二钠;穿心莲乙素;穿心莲乙素植物提取物,标准品,对照品;穿心莲总内酯;对甲基氯化苄;分析对照品;柴胡皂苷B;橙皮素;穿心莲素;滇乌头碱;碘化木兰花碱;雄茸内脂;印乌头碱;兽用穿心莲提取物
英文名称	Andrographolide
英文别名	Andrographolide;ANDRO;ANDROGRAPHIS;3A,14,15,18-TETRAHYDROXY-5B,9B,H,10A-LAMBDA-8,20-DIENE;2(3H)-FURANONE,3-[2-[(1R,4AS,5R,6R,8AS)-DECAHYDRO-6-HYDROXY-5-(HYDROXYMETHYL)-5,8A-DIMETHYL-2-METHYLENE-1-NAPHTHALENYL]ETHYLIDENE]DIHYDRO-4-HYDROXY-, (3E,4S)-;2(3h)-furanone,3-(2-(decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-met;hylene-1-naphthalenyl)ethylidene)dihydro-4-hydroxy-,(1r-(1-alpha(e(s*)),4a-be;(S,E)-4-Hydroxy-3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethylidene)dihydrofuran-2(3H)-one;ANDROGRAPHOLIDE(P);ANDROGRAPHOLIDE(SH) PrintBack;alpha-Chloro-p-xylene;Andrographalide;Andrographolid;Rhizoma Sparganii;(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone;ent-(3β,12E,14R)-3,14,19-Trihydroxy-8(17),12-labdadien-16,15-olide;andrographolidume;[ "" ];410105JHGR;Andropanolide;3-(2-(Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenenaphthyl)ethylidene)dihydro-4-hydroxyfuran-2(3H)-one;(3E,4S)-4-hydroxy-3
Cas No.	5508-58-7
分子式	C₂₀H₃₀O₅
分子量	350.45
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Andrographolide is a NF-κB inhibitor, which inhibits NF-κB activation through covalent modification of a cysteine residue on p50 in endothelial cells without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide has antiviral effects.
性状	Solid
IC50 & Target[1][2]	p50

体外研究(In Vitro)

Andrographolide (AP) concentration-dependently suppresses receptor activator of nuclear factor kappa B ligand (RANKL)-mediated osteoclast differentiation and bone resorption in vitro and reduces the expression of osteoclast-specific markers. Andrographolide attenuates inflammation by inhibition of TNFα-induced NF-κB activation through covalent modification of reduced Cys of p50, without affecting IκBα degradation or p50/p65 nuclear translocation. Andrographolide also inhibits the ERK/MAPK signalling pathway without affecting p38 or JNK signalling. Andrographolide inhibits osteoclast differentiation of RAW 264.7 cells in a concentration-dependent manner.Andrographolide suppresses osteoclast formation in a concentration-dependent manner without any obvious cytotoxic effects, in both BMMs and RAW 264.7 cells. Andrographolide treatment substantially reduces the area of bone reso

体内研究(In Vivo)

Treatment with Andrographolide (5 or 30?mg/kg) reduces the extent of bone loss induced by LPS. Moreover, Andrographolide slightly increases the BMD and cortex thickness compared to LPS treatment. Histological examination confirms the protective effects of Andrographolide on LPS-induced bone loss. LPS injection leads to inflammatory bone erosion and increased numbers of TRAP-positive osteoclasts.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Terpenoids
Diterp

来源

Plants

溶解度数据	体外研究: DMSO : 100 mg/mL(285.35 mM;Need ultrasonic) H₂O : 0.1 mg/mL(0.29 mM;Need ultrasonic) 配制储存液

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