Taraxerol is isolated from Taraxacum mongolicum, and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition ofNF-κB signaling pathway. Taraxerol induces cell apoptosis.

Solid

IC50: apoptosis

Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95%(20 μM), 89.8%(40 μM), 82.6 %(60 μM), 72.9 % (80 μM), and 63.6%(100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6%at the 100 μM concentration at 48 hours in Hela cells.
Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining,significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Taraxerol (5 and 10mg/kg; i.p.)attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transport.

4°C, Keep In Dark；*In solvent : -80°C, 6 months; -20°C, 1 month (Keep In Dark)；

Terpenoids
Triter

Plants

体外研究:
THF : 10 mg/mL(23.43 mM;Need ultrasonic)
H₂O : < 0.1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble)