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Tanshinone IIA sulfonate sodium

(Synonyms: 丹参酮IIA磺酸盐; Sodium Tanshinone IIA sulfonate; Tanshinone IIA sodium sulfonate)

目录号: PC64101 纯度: ≥98.0%

Tanshinone IIA sulfonate sodium 是 tanshinone IIA 的衍生物，为 SOCE 的抑制剂，用于心血管疾病的研究。Tanshinone IIA sulfonate sodium 是 tanshinone IIA 的衍生物，为 SOCE 的抑制剂，用于心血管疾病的研究。

CAS No. :69659-80-9

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中文名称	Tanshinone IIA sulfonate sodium
中文别名	丹参酮IIA-磺酸钠;丹参酮IIA磺酸钠;zzstandard 品牌丹参酮IIA-磺酸钠对照品;丹参酮ⅡA磺酸钠;丹参酮ⅡA磺酸钠、丹参酮IIA磺酸钠;丹参酮IIA;丹参酮IIA磺酸钠 Tanshinone IIA Sulfonate Sodium;丹参酮IIA-磺酸钠标准品;丹参酮IIA-磺酸钠（标准品）;丹参酮IIA磺酸盐
英文名称	Tanshinone IIA sulfonate sodium
英文别名	Sodium 1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-sulfonate;Tanshinone IIA-sulfonic sodium;Phenanthro[1,2-b]furan-2-sulfonicacid, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-, s...;Phenanthro[1,2-b]furan-2-sulfonicacid, 6,7,8,9,10,11-hexahydro-1,6,6-trimethyl-10,11-dioxo-, sodium salt (1:1);SODIUM TANSHINONE IIA SULFONATE;sodium,1,6,6-trimethyl-10,11-dioxo-8,9-dihydro-7H-naphtho[1,2-g][1]benzofuran-2-sulfonate;Tanshinone ⅡA Sulfonate Sodium;Tanshinone IIA sodium sulfonate;Tanshinone IIA sulfonate (sodium);Sulfotanshinone sodium II-A;Tanshinone II A sodium sulfonate;TANSHINONE IIA SULFONATE SODIUM;IVJ88KQ4XN;tanshinone IIA sulfonate;AK128306;TanshinoneIIA;Sodium tanshinone II A sulfonate;DS 201;Sulfotanshinone IIA Sodium;SPECTRUM1505036;ta;TIIAS;Sodium Tanshinone IIA sulfonate;Tanshinone IIA sodium sulfonate
Cas No.	69659-80-9
分子式	C₁₉H₁₇NaO₆S
分子量	396.39
包装储存	4°C, sealed storage and away from moisture；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

生物活性

Tanshinone IIA sulfonate (sodium) is a derivative of tanshinone IIA, which acts as an inhibitor of store-operated Ca entry (SOCE), and is used to treat cardiovascular disorders.

性状

Solid

体外研究(In Vitro)

Sodium Tanshinone IIA sulfonate (12.5 μM) inhibits hypoxia-induced PKG and PPAR-γ downregulation in PASMCs and distal pulmonary arteries of rats. The suppressive effects of Sodium Tanshinone IIA sulfonate on TRPC1 and TRPC6 expression in hypoxic PASMCs can be prevented by specific knockdown PKG or PPAR-γ. The suppressive effects of Sodium Tanshinone IIA sulfonate on basal calcium concentration and SOCE in hypoxic PASMCs can be reversed by specific knockdown of PKG or PPAR-γ. PKG-PPAR-γ signaling axis participates in the suppressive effects of Sodium Tanshinone IIA sulfonate on proliferation in hypoxic PASMCs. PPAR-γ agonist promotes the protective role of Sodium Tanshinone IIA sulfonate on basal [Ca]i and SOCE in hypoxic PASMCs. Sodium tanshinone IIA sulfonate inhibits the activity of CYP3A4 in a dose-dependent manner by the HLMs and CYP3A4 isoform. The KM and Vmax

体内研究(In Vivo)

Sodium Tanshinone IIA sulfonate (10 mg/kg, 20 mg/kg) and Donepezil shorten escape latency, increase crossing times of the original position of the platform, and increase the time spent in the target quadrant. Sodium Tanshinone IIA sulfonate decreases the activity of acetylcholinesterase (AChE) and increases the activity of choline acetyltransferase (ChAT) in the hippocampus and cortex of SCOP-treated mice. Sodium Tanshinone IIA sulfonate increases the activity of superoxide dismutase (SOD) and decreases the levels of malondialdehyde (MDA) and reactive oxygen species (ROS) in hippocampus and cortex. Sodium Tanshinone IIA sulfonate prevention (30 mg/kg/day) alleviates hypoxia-induced characteristic changes in chronic hypoxia PH rat model. Sodium Tanshinone IIA sulfonate (20, 10, and 5 mg/kg, i.p.) effectively prevents peritoneal adhesion without affecting anastomotic healing in

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*该产品在溶液状态不稳定，建议您现用现配，即刻使用。；

ClinicalTrial

结构分类

Terpenoids
Diterp

来源

Plants

溶解度数据	体外研究: DMSO : 62.5 mg/mL(157.67 mM;Need ultrasonic) H₂O : 8.33 mg/mL(21.01 mM;Need ultrasonic) 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Tanshinone IIA sulfonate sodium

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