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Squalamine lactate

(Synonyms: MSI-1256F)

目录号: PC64411 纯度: ≥98%

Squalamine lactate 是一种从角鲨体内分到的氨基甾醇，具有抗菌活性，同时可用于新生血管性年龄相关性黄斑变性的研究。Squalamine lactate 是一种从角鲨体内分到的氨基甾醇，具有抗菌活性，同时可用于新生血管性年龄相关性黄斑变性的研究。

CAS No. :320725-47-1

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中文名称	Squalamine lactate
英文名称	Squalamine lactate
英文别名	(2S)-2-hydroxypropanoic acid - (3beta,5alpha,7alpha,24R)-3-({3-[(4-aminobutyl)amino]propyl}amino)-7-hydroxycholestan-24-yl hydrogen sulfate (1:1);Squalamine lactate;squalamine L-lactate;BB0CTI216I;Squalamine lactate [USAN];MSI 1256F;C34H65N3O5S.C3H6O3;Y1924;Q27274574
Cas No.	320725-47-1
分子式	C₃₇H₇₁N₃O₈S
分子量	718.04
包装储存	4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性

Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity, and used for the treatment of neovascular age-related macular degeneration.

性状

Solid

体外研究(In Vitro)

Squalamine lactate has a more generalized effect on the cellular signaling cascade that is common to both VEGF and other growth factors. Squalamine blocks the action of VEGF and integrin expression, thereby inhibiting angiogenesis, when bound to calmodulin.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Squalamine is ineffective when administered intravitreally and therefore requires intravenous dosing. However, systemic dosing has yielded promising results in rats as well as humans.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

4°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

ClinicalTrial

结构分类

Terpenoids
Triter

来源

Squalus acanthias

溶解度数据	体外研究: DMSO : ≥ 36.66 mg/mL(51.06 mM) *≥ means soluble, but saturation unknown. 配制储存液

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Data Sheet

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

Squalamine lactate

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