Cholesterol |57-88-5|甾体类|PC66792-1mg|Medlife,上海现货

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★Cholesterol

Cholesterol 是一种哺乳动物中的主要固醇，占质膜结构成分的 20-25％。质膜对水具有高渗透性，但对离子和质子则相对不可渗透。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是一种内源性雌激素相关受体 α (ERRα) 激动剂。Cholesterol 是一种哺乳动物中的主要固醇，占质膜结构成分的 20-25％。质膜对水具有高渗透性，但对离子和质子则相对不可渗透。Cholesterol 在确定膜的流动性和渗透性特征以及转运蛋白和信号蛋白的功能中起着重要作用。Cholesterol 还是一种内源性雌激素相关受体 α (ERRα) 激动剂。

目录号: PC66792 纯度: ≥98%

CAS No. :57-88-5

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中文名称	★Cholesterol
中文别名	胆固醇;胆固醇,参比液;胆固醇,标准液;(3β)-胆甾-5-烯-3-醇;胆甾-5-烯-3β-醇;胆脂醇;异辛甾烯醇;胆甾醇;胆甾烷醇;胆固烯醇;Cholesterol (stabilized with alpha-Tocopherol) 胆固醇;胆固醇 Cholesterol;胆固醇 EP标准品;胆固醇标准品;胆固醇,Merck;胆固醇,半合成品;胆固醇,对照品;胆固醇纯度标准物质;胆甾-5-烯3β醇;高纯胆固醇;实验专用胆固醇;胆固;胆固醇,Cholesterol,AR;胆固醇纯度标准物质;胆甾醇;胆甾醇烷;异辛甾烯醇;胆固烯醇;胆脂醇;胆脂素;胆脂素醇;左旋倍他洛尔;合成胆固醇;胆固醇素;胆甾烷醇 (含稳定剂α-生育酚);胆甾醇 (含稳定剂α-生育酚)
英文名称	Cholesterol
英文别名	6-Cholesten-3b-ol;5-Cholesten-3beta-ol;cholesterol from lanolin;cholesterol from hog liver;Cholesterol, NF;(3beta)-cholest-5-en-3-ol;(3.beta.)-Cholest-5-en-3-ol;(3β)-cholest-5-en-3-ol;3β-hydroxycholest-5-ene;5,6-Cholesten-3beta-ol;5:6-cholesten-3-beta-ol;5:6-Cholesten-3beta-ol;5-Cholesten-3B-ol;5-cholesten-3β-ol;Cholest-5-en-3beta-ol;3beta-hydroxycholest-5-ene;3beta-hydroxy-5-cholestene;Cholesterol (stabilized with alpha-Tocopherol);Cholest-5-en-3-ol;Cholest-5-en-3β-ol;Cholesterol;CHOLESTEROL (AS);Cholesterol solution;Cholesterol, Semi-synthetic;20-Dihydro Cortexolone;20-Dihydro-11-deoxycortisol;3β-Hydroxy-5-cholestene;cholesterin;cholest-5-en-3β-ol ; 110796;cholest-5-en-3β-ol; 110797;CHO-HP;Cholesteryl alcohol;Cholestrin;Dusoline;Dusoran;Cordulan;Cholesterine;Cholestrol;Hydrocerin;Kathro;Dythol;Lanol;Super hartolan;Provitamin D;Cholesterol base H;Lidinite;Lidinit;Nimco cholesterol base H;Wool alcohols B. P.;(-)-Cholesterol;Tegolan (VAN);Cholest-5-en-3-beta-ol;Tegolan;Cholest-5-en-3-ol (3beta)-;3-beta-Hydroxycholest-5-ene
Cas No.	57-88-5
分子式	C₂₇H₄₆O
分子量	386.65
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性

Cholesterol is the major sterol in mammals and is makes up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.

性状

Solid

IC50 & Target[1][2]

Microbial Metabolite
Human Endogenous Metabolite

体外研究(In Vitro)

GT1-7 hypothalamic cells subjected to Cholesterol depletion in vitro produced 20-31% reductions in cellular Cholesterol content. All Cholesterol-depleted neuron-derived cells, exhibit decreased phosphorylation/activation of IRS-1 and AKT following stimulation by insulin, insulin-like growth factor-1, or the neurotrophins (NGF and BDNF). Reduction in cellular Cholesterol also results in increased basal autophagy and impairment of induction of autophagy by glucose deprivation.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究(In Vivo)

Insulin-deficient diabetes in mice can lead to a reduction in brain Cholesterol synthesis, which occurs through a change in expression of Cholesterol synthesis enzymes and their upstream regulators SREBP2 and SCAP1.
The pool of Cholesterol in the whole animal is 2,200 mg/kg body weight. This is true for essentially all species from the mouse to the primate and indicates that the average concentration of Cholesterol in the whole animal is 2.2 mg/g fresh tissue.
The basal metabolic rate in the mouse is 170 kilocalories (kcal)/day/kg, and the flow of Cholesterol from all peripheral organs to the liver is greater than 100 mg/day/kg.Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

运输条件

Room temperature or refrigerated transport.

储存方式

Powder； -20°C； 3 years; 4°C； 2 years；

ClinicalTrial

结构分类

Steroids

溶解度数据	体外研究: Ethanol : 14.29 mg/mL(36.96 mM;Need ultrasonic) DMSO : < 1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble or slightly soluble) 配制储存液

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1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

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