Garcinol|78824-30-3|(山竹子素)-陌孚医药/Medlife

您当前的位置：

Garcinol (Synonyms: 山竹子素)

目录号: PC58276 纯度: ≥98%

CAS No. :78824-30-3

Medlife所售产品仅用于科学研究（非临床研究），非药品不可食用，不可用于人体或动物的临床诊断和治疗，我们不为个人提供产品及服务。产品COA等资料，可至下方“质量控制”中下载。

加入购物车在线咨询收藏产品大包装询价

中文名称	Garcinol
中文别名	山竹子素
英文名称	Garcinol
英文别名	garcinol;(1R,3E,5R,7R)-3-[(3,4-dihydroxyphenyl)-hydroxy-methylidene]-8,8-dimethyl-1,7-bis(3-methylbut-2-enyl)-5-[(2S)-5-methyl-2-prop-1-en-2-yl-hex-4-enyl]bicyclo[3.3.1]nonane-2,4,9-trione;Bicyclo[3.3.1]non-3-ene-2,9-dione,3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-me...;Bicyclo[3.3.1]non-3-ene-2,9-dione,3-(3,4-dihydroxybenzoyl)-4-hydroxy-8,8-dimethyl-1,7-bis(3-methyl-2-buten-1-yl)-5-[(2S)-5-me;Garcinol (Camboginol);guttiferone F
Cas No.	78824-30-3
分子式	C₃₈H₅₀O₆
分子量	602.80
包装储存	-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；

生物活性	Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC₅₀s of 0.66 μM and 7.39 μM, respectively. Garcinol also inhibits histone acetyltransferases (HATs, IC₅₀= 7 μM) and p300/CPB-associated factor (PCAF, IC₅₀ = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity.
性状	Solid
IC50 & Target[1][2]	AChE BChE
体外研究(In Vitro)	Garcinol (10-50 μM; 24-72 hours) can inhibit the proliferation of two HNSCC cell lines tested (CAL27 and UMSCC1) in a time- and dose-dependent manner. Garcinol (10-50 μM; 24-72 hours) induces apoptosis in HNSCC cells. Garcinol (50 μM; 1-6 hours) suppresses phosphorylation and degradation of the constitutive IκBα in a time-dependent manner. Medlife has not independently confirmed the accuracy of these methods. They are for reference only. ass="cpd-vitro-list"> Cell Prolif
体内研究(In Vivo)	Garcinol (i.p.; 1 and 2 mg/kg; five times/week for 4 consecutive weeks) induces significant inhibition of tumor growth. Medlife has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:Five-week-
运输条件	Room temperature or refrigerated transport.
储存方式	-20°C, sealed storage and away from moisture；*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage and away from moisture)；
结构分类	Phenols Polypheno
来源	Plants

溶解度数据	体外研究: DMSO : 50 mg/mL(82.95 mM;Need ultrasonic) Ethanol : 20 mg/mL(33.18 mM;Need ultrasonic and warming) 配制储存液

搜索质检报告(COA)

1：一般建议：溶解度为Medlife测试数据，可能与文献描述存在差异。这是由于生产工艺和批次不同产生的正常现象。为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同批次产品溶解度各有差异，仅做参考，具体以实验方案为准。

2：储存条件：粉末-20°C一般情况可以保存3年，溶于溶剂-80°C一般情况可以保存1年。不同产品及不同批次产品可能存在差异，请细致阅读产品信息，并辅助参考相关文献描述。

相关产品