Imperatorin|482-44-0|(欧前胡素; Ammidin)-陌孚医药/Medlife

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Imperatorin (Synonyms: 欧前胡素; Ammidin)

目录号: PC57626 纯度: ≥98%

CAS No. :482-44-0

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中文名称	Imperatorin
中文别名	欧前胡素;白茅苷;前胡素;主人草素;白芷乙素;欧芹属素乙;前胡内酯;Imperatorin 欧前胡素标准品;白芷提取物欧前胡素;欧前胡素 EP标准品;欧前胡素 Imperatorin;欧前胡素(AS);欧前胡素（标准品）;欧前胡素,Imperatorin,植物提取物,标准品,对照品;前胡;欧前胡素(欧芹属素乙,前胡内酯,白芷乙素, 白茅苷,前胡素,主人草素);前胡内酯,白芷乙素;8-异戊烯氧基补骨脂素;9-[(3-甲基-2-丁烯-1-基)氧]-7H-呋喃并[3,2-g]色满-7-酮;8-(3-甲基-2-丁烯氧基)补骨脂素
英文名称	Imperatorin
英文别名	Imperatorin;2-g)(1)benzopyran-7-one,9-((3-methyl-2-butenyl)oxy)-7h-furo(;6-hydroxy-7-((3-methyl-2-butenyl)oxy)-5-benzofuranacrylicacidelta-lacto;6-hydroxy-7-((3-methyl-2-butenyl)oxy)-5-benzofuranacrylicacidelta-lactone;6-hydroxy-7-(3-methyl-2-butenyloxy)-5-benzofuranacrylicacidomega-lactone;8-isopentenyloxypsoralene;9-((3-methyl-2-butenyl)oxy)-7h-furo(3,2-g)(1)benzopyran-7-one;9-[(3-methyl-2-butenyl)oxy]-7h-furo[3,2-g][1]benzopyran-7-one;7H-Furo[3,2-g][1]benzopyran-7-one,9-[(3-methyl-2-buten-1-yl)oxy]-;Ammidin;IMPERATORIN(AS) PrintBack;IMPERATORIN(P);Marmelosin;MARMELOSIN (IMPERATORIN)(RG);8-ISOAMYLEN;Enoxypsoralen;Marmelide;Pentosalen;9-(3-Methylbut-2-enyloxy)-7H-furo[3,2-g]chromen-7-one;9-[(3-METHYL-2-BUTEN-1-YL)OXY]-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE;NSC 402949;9-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one;8-(3-Methyl-2-butenyloxy)psoralen;8-Prenyloxypsoralen;8-Isopentenyloxypsoralen;[ "" ];8-Isoamylenoxypsoralen;9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one;7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]-;9-(3-Methylbut-2-enyloxy)furo(3,2-g)chromen-7-one;OLOOJGVNMBJLLR-UHFFFAOYSA-N;9-(3-Methylbut-2-enyloxy)furo[3,2-g]chromen-7-one;K713N25C78;9-(3-Methylbut-2-enyloxy)-7
Cas No.	482-44-0
分子式	C₁₆H₁₄O₄
分子量	270.28
包装储存	Powder； -20°C； 3 years; 4°C； 2 years；

生物活性	Imperatorin is an effective of NO synthesis inhibitor (IC₅₀=9.2 μmol), which also is a BChE inhibitor (IC₅₀=31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC₅₀ of 12.6±3.2 μM.
性状	Solid
IC50 & Target[1][2]	AChE BChE
体外研究(In Vitro)	Imperatorin is a plant secondary metabolite belonging to the coumarins-specifically the furanocoumarins. Imperatorin enhances the GABA-induced chloride ion current (IGABA) through the α1β2γ2S receptors. Imperatorin potentiates IGABA at 100 μmol by 50.5±16.3 % and at 300 μmol by 109.8±37.7 %, respectively. Imperatorin, together with Phellopterin, found in the roots of A. dahurica, inhibit [H]diazepam binding to the benzodiazepine site of the rat brain GABAA receptor in vitro with an IC50 of 12.3 μmol for Imperatorin and 400 nmol for Phellopterin. Imperatorin, in a concentration ranging from 3.5 to 14 mmol, significantly and irreversibly inhibits GABA-T in a time-dependent and concentration-dependent manner, by irreversibly binding with the active site of GABA-T.Imperatorin is a reversible acetylcholine
体内研究(In Vivo)	At doses of 10 and 20 mg/kg and 30 min after injection, Imperatorin shows an anxiolytic effect and improved different stages of memory and learning processes-both acquisition and consolidation. It is also shown that acute administration Imperatorin at doses of 10 and 20 mg/kg reduced the anxiogenic effect of nicotine (0.1 mg/kg, subcutaneous, s.c.). At 30 and 40 mg/kg, i.p. Imperatorin significantly potentiates the anticonvulsant activity of carbamazepine against maximal electroshock-induced seizures expressed by lowering the ED50 from 10.8 to 6.8 mg/kg (by 34 %) and 6 mg/kg (by 42 %), respectively. Moreover, Imperatorin at 30 mg/kg and carbamazepine at 6.8 mg/kg shows increases the total brain concentration of carbamazepine from 1.260 to 2.328 μg/mL (by 85%), which may be caused by modifying the blood-barrier permeability or acting like an inhibitor of multi-drug r
运输条件	Room temperature or refrigerated transport.
储存方式	Powder； -20°C； 3 years; 4°C； 2 years；
结构分类	Phenylpropanoids
来源	Plants

溶解度数据	体外研究: DMSO : 50 mg/mL(184.99 mM;Need ultrasonic) 配制储存液

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