H2L 5765834 is an antagonist of lysophosphatidic acid receptors LPA₁, LPA₃, and LPA₅, with IC₅₀s of 94, 752, and 463 nM respectively.

Solid

H2L 5765834 displays no effect on LPA₂ or LPA₄ receptors.
H2L 5765834 inhibits LPA-induced platelet shape change with an IC₅₀ of 13.73±2.52 μM.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

H2L 5765834 (20 mg/kg; i.p.) could not affect the LPA-induced decrease of alanine transaminase (ALT) in the acetaminophen (APAP) overdose-induced acute liver injury model.

Medlife has not independently confirmed the accuracy of these methods. They are for reference only.

Room temperature or refrigerated transportation.

• [1]. Williams JR, et, al. Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation. J Biol Chem. 2009 Jun 19; 284(25): 17304-19.  [Information]

  [2]. Bae GH, et, al. Lysophosphatidic acid protects against acetaminophen-induced acute liver injury. Exp Mol Med. 2017 Dec 8; 49(12): e407.  [Information]

产品不同，其溶解度不同。建议根据产品选择合适的溶剂配制储备溶液；配成溶液后，建议分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，建议在 6 个月内使用，-20°C 储存时，建议在 1 个月内使用。